Journal article
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The Role of Epigenetic Clocks in Explaining Educational Inequalities in Mortality: A Multicohort Study and Meta-analysis
DOKPE
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Carmeli, Cristian
ORCID
University of Fribourg
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Fiorito, Giovanni
ORCID
University of Sassari
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Pedron, Sara
Institute of Health Economics and Health Care Management, Helmholtz Zentrum München
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Ochoa-Rosales, Carolina
Department of Epidemiology, Erasmus MC, Rotterdam
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McCrory, Cathal
ORCID
Department of Medical Gerontology, Trinity College Dublin
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Polidoro, Silvia
Italian Institute for Genomic Medicine (IIGM), Turin
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Zhang, Yan
ORCID
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Munich
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Dugué, Pierre-Antoine
ORCID
Cancer Epidemiology Division, Cancer Council Victoria, Australia
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Ratliff, Scott
Department of Epidemiology, School of Public Health, University of Michigan
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Zhao, Wei N
Department of Epidemiology, School of Public Health, University of Michigan
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McKay, Gareth J
ORCID
Centre for Public Health, Queen’s University Belfast
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Costa, Giuseppe
Epidemiology Unit, Regional Health Service TO3, Grugliasco
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Solinas, Maria Giuliana
Departmentof Biomedical Sciences, University of Sassari
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Harris, Kathleen Mullan
Department of Sociology, University of North Carolina
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Tumino, Rosario
ORCID
Cancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), Ragusa
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Grioni, Sara
ORCID
Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano
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Ricceri, Fulvio
ORCID
Epidemiology Unit, Regional Health Service TO3, Grugliasco
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Panico, Salvatore
ORCID
Dipartimento di Medicina Clinica e Chirurgia, University of Naples Federico II
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Brenner, Hermann
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Munich
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Schwettmann, Lars
Institute of Health Economics and Health Care Management, Helmholtz Zentrum München
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Waldenberger, Melanie
Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München,
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Matias-Garcia, Pamela R
Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München
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Peters, Annette
ORCID
Institute of Epidemiology, Helmholtz Zentrum München
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Hodge, Allison
Cancer Epidemiology Division, Cancer Council Victoria
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Giles, Graham G
Cancer Epidemiology Division, Cancer Council Victoria, Victoria, Australia
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Schmitz, Lauren L
Robert M. La Follette School of Public Affairs, University of Wisconsin-Madison
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Levine, Morgan
Department of Pathology, Yale University School of Medicine
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Smith, Jennifer A.
ORCID
Centre for Public Health, Queen’s University Belfast
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Liu, Yongmei
Division of Cardiology, Department of Medicine, School of Medicine, Duke University
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Kee, Frank
Centre for Public Health, Queen’s University Belfast
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Young, Ian S
Centre for Public Health, Queen’s University Belfast
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McGuinness, Bernadette
Centre for Public Health, Queen’s University Belfast
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McKnight, Amy Jayne
Centre for Public Health, Queen’s University Belfast
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van Meurs, Joyce
Department of Internal Medicine, Erasmus MC, Rotterdam
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Voortman, Trudy
ORCID
Department of Epidemiology, Erasmus MC, Rotterdam
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Kenny, Rose A
Department of Medical Gerontology, Trinity College Dublin, Dublin
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Lifepath consortium
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Vineis, Paolo
ORCID
MRC Centre for Environment and Health, School of Public Health, Imperial CollegeLondon
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Published in:
- The Journals of Gerontology: Series A. - 2022, vol. 77, no. 9, p. 1750-1759
English
Educational inequalities in all-cause mortality have been observed for decades. However, the underlying biological mechanisms are not well known. We aimed to assess the role of DNA methylation changes in blood captured by epigenetic clocks in explaining these inequalities. Data were from 8 prospective population-based cohort studies, representing 13 021 participants. First, educational inequalities and their portion explained by Horvath DNAmAge, Hannum DNAmAge, DNAmPhenoAge, and DNAmGrimAge epigenetic clocks were assessed in each cohort via counterfactual-based mediation models, on both absolute (hazard difference) and relative (hazard ratio) scales, and by sex. Second, estimates from each cohort were pooled through a random effect meta-analysis model. Men with low education had excess mortality from all causes of 57 deaths per 10 000 person-years (95% confidence interval [CI]: 38, 76) compared with their more advantaged counterparts. For women, the excess mortality was 4 deaths per 10 000 person-years (95% CI: −11, 19). On the relative scale, educational inequalities corresponded to hazard ratios of 1.33 (95% CI: 1.12, 1.57) for men and 1.15 (95% CI: 0.96, 1.37) for women. DNAmGrimAge accounted for the largest proportion, approximately 50%, of the educational inequalities for men, while the proportion was negligible for women. Most of this mediation was explained by differential effects of unhealthy lifestyles and morbidities of the World Health Organization (WHO) risk factors for premature mortality. These results support DNA methylation-based epigenetic aging as a signature of educational inequalities in life expectancy emphasizing the need for policies to address the unequal social distribution of these WHO risk factors.
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Faculty
- Faculté des sciences et de médecine
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Department
- Master en médecine
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Language
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Classification
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Pathology, clinical medicine
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License
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License undefined
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Open access status
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green
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/320223
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