A standard numbering scheme for class c β-lactamases

Mack, Andrew R.; Barnes, Melissa D.; Taracila, Magdalena A.; Hujer, Andrea M.; Hujer, Kristine M.; Cabot, Gabriel; Feldgarden, Michael; Haft, Daniel H.; Klimke, William; Akker, Focco van den; Vila, Alejandro J.; Smania, Andrea; Haider, Shozeb; Papp-Wallace, Krisztina M.; Bradford, Patricia A.; Rossolini, Gian Maria; Docquier, Jean-Denis; Frère, Jean-Marie; Galleni, Moreno; Hanson, Nancy D.; Oliver, Antonio; Plésiatyz, Patrick; Poirel, Laurent; Nordmann, Patrice; Palzkill, Timothy G.; Jacoby, George A.; Bush, Karen; Bonomo, Robert A.

doi:10.1128/AAC.01841-19

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A standard numbering scheme for class c β-lactamases

Mack, Andrew R. Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA - Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA
Barnes, Melissa D. Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA - Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA
Taracila, Magdalena A. Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA - Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA
Hujer, Andrea M. Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA - Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA
Hujer, Kristine M. Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA - Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA
Cabot, Gabriel Red Española de Investigación en Patología Infecciosa (REIPI), Instituto de Salud Carlos III, Madrid, Spain - Servicio de Microbiología, Hospital Universitario Son Espases, Instituto de Investigación Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain
Feldgarden, Michael National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA
Haft, Daniel H. National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA
Klimke, William National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA
Akker, Focco van den Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA
Vila, Alejandro J. CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio, USA - Instituto de Biología Molecular y Celular de Rosario (IBR, CONICET-UNR), Rosario, Argentina - Plataforma Argentina de Biología Estructural y Metabolómica PLABEM, Buenos Aires, Argentina - Área Biofísica, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina
Smania, Andrea Centro de Investigaciones en Química Biológica de Córodoba (CIQUIBIC), CONICET, Universidad Nacional de Córdoba, Córdoba, Argentina - Departamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina
Haider, Shozeb UCL School of Pharmacy, University College London, London, United Kingdom
Papp-Wallace, Krisztina M. Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA - Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA - Department of Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio, USA - Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA
Bradford, Patricia A. Antimicrobial Development Specialists, LLC, Nyack, New York, USA
Rossolini, Gian Maria Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy - Microbiology and Virology Unit, Florence Careggi University Hospital, Florence, Italy
Docquier, Jean-Denis Department of Medical Biotechnology, University of Siena, Siena, Italy
Frère, Jean-Marie Centre for Protein Engineering (CIP), University of Liège, Liège, Belgium
Galleni, Moreno Centre for Protein Engineering (CIP), University of Liège, Liège, Belgium
Hanson, Nancy D. Department of Microbiology and Immunology, Creighton School of Medicine, Omaha, Nebraska, USA
Oliver, Antonio Red Española de Investigación en Patología Infecciosa (REIPI), Instituto de Salud Carlos III, Madrid, Spain - Servicio de Microbiología, Hospital Universitario Son Espases, Instituto de Investigación Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain
Plésiatyz, Patrick Centre National de Référence de la Résistance aux Antibiotiques, Besançon, France
Poirel, Laurent Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland - Swiss National Reference Center for Emerging Antibiotic Resistance (NARA), University of Fribourg, Fribourg, Switzerland
Nordmann, Patrice Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland - Swiss National Reference Center for Emerging Antibiotic Resistance (NARA), University of Fribourg, Fribourg, Switzerland
Palzkill, Timothy G. Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas, USA - Verna Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA
Jacoby, George A. Lahey Hospital and Medical Center, Burlington, Massachusetts, USA
Bush, Karen Department of Biology, Indiana University Bloomington, Bloomington, Indiana, USA
Bonomo, Robert A. Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA - Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA - Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA - Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA

21.02.2020

Published in:

Antimicrobial Agents and Chemotherapy. - 2020, vol. 64, no. 3, p. 10.1128/aac.01841-19

English Unlike for classes A and B, a standardized amino acid numbering scheme has not been proposed for the class C (AmpC) β-lactamases, which complicates communication in the field. Here, we propose a scheme developed through a collaborative approach that considers both sequence and structure, preserves traditional numbering of catalytically important residues (Ser64, Lys67, Tyr150, and Lys315), is adaptable to new variants or enzymes yet to be discovered and includes a variation for genetic and epidemiological applications.

Faculty

Faculté des sciences et de médecine

Department

Médecine 3ème année

Language