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A standard numbering scheme for class c β-lactamases

  • Mack, Andrew R. Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA - Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA
  • Barnes, Melissa D. Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA - Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA
  • Taracila, Magdalena A. Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA - Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA
  • Hujer, Andrea M. Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA - Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA
  • Hujer, Kristine M. Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA - Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA
  • Cabot, Gabriel Red Española de Investigación en Patología Infecciosa (REIPI), Instituto de Salud Carlos III, Madrid, Spain - Servicio de Microbiología, Hospital Universitario Son Espases, Instituto de Investigación Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain
  • Feldgarden, Michael National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA
  • Haft, Daniel H. National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA
  • Klimke, William National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA
  • Akker, Focco van den Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA
  • Vila, Alejandro J. CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio, USA - Instituto de Biología Molecular y Celular de Rosario (IBR, CONICET-UNR), Rosario, Argentina - Plataforma Argentina de Biología Estructural y Metabolómica PLABEM, Buenos Aires, Argentina - Área Biofísica, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina
  • Smania, Andrea Centro de Investigaciones en Química Biológica de Córodoba (CIQUIBIC), CONICET, Universidad Nacional de Córdoba, Córdoba, Argentina - Departamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina
  • Haider, Shozeb UCL School of Pharmacy, University College London, London, United Kingdom
  • Papp-Wallace, Krisztina M. Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA - Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA - Department of Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio, USA - Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA
  • Bradford, Patricia A. Antimicrobial Development Specialists, LLC, Nyack, New York, USA
  • Rossolini, Gian Maria Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy - Microbiology and Virology Unit, Florence Careggi University Hospital, Florence, Italy
  • Docquier, Jean-Denis Department of Medical Biotechnology, University of Siena, Siena, Italy
  • Frère, Jean-Marie Centre for Protein Engineering (CIP), University of Liège, Liège, Belgium
  • Galleni, Moreno Centre for Protein Engineering (CIP), University of Liège, Liège, Belgium
  • Hanson, Nancy D. Department of Microbiology and Immunology, Creighton School of Medicine, Omaha, Nebraska, USA
  • Oliver, Antonio Red Española de Investigación en Patología Infecciosa (REIPI), Instituto de Salud Carlos III, Madrid, Spain - Servicio de Microbiología, Hospital Universitario Son Espases, Instituto de Investigación Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain
  • Plésiatyz, Patrick Centre National de Référence de la Résistance aux Antibiotiques, Besançon, France
  • Poirel, Laurent Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland - Swiss National Reference Center for Emerging Antibiotic Resistance (NARA), University of Fribourg, Fribourg, Switzerland
  • Nordmann, Patrice Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland - Swiss National Reference Center for Emerging Antibiotic Resistance (NARA), University of Fribourg, Fribourg, Switzerland
  • Palzkill, Timothy G. Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas, USA - Verna Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA
  • Jacoby, George A. Lahey Hospital and Medical Center, Burlington, Massachusetts, USA
  • Bush, Karen Department of Biology, Indiana University Bloomington, Bloomington, Indiana, USA
  • Bonomo, Robert A. Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA - Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA - Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA - Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA
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    21.02.2020
Published in:
  • Antimicrobial Agents and Chemotherapy. - 2020, vol. 64, no. 3, p. 10.1128/aac.01841-19
English Unlike for classes A and B, a standardized amino acid numbering scheme has not been proposed for the class C (AmpC) β-lactamases, which complicates communication in the field. Here, we propose a scheme developed through a collaborative approach that considers both sequence and structure, preserves traditional numbering of catalytically important residues (Ser64, Lys67, Tyr150, and Lys315), is adaptable to new variants or enzymes yet to be discovered and includes a variation for genetic and epidemiological applications.
Faculty
Faculté des sciences et de médecine
Department
Médecine 3ème année
Language
  • English
Classification
Biological sciences
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/309178
Other files
Supplementary material
Supplementary material
SequenceAlignment.txt
SequenceAlignment.txt
SecondaryStructureAlignment.txt
SecondaryStructureAlignment.txt
RegionalAnnotation.txt
RegionalAnnotation.txt
Supplementary material 2
Supplementary material 2
Statistics
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  • SequenceAlignment.txt: 70
  • SecondaryStructureAlignment.txt: 55
  • RegionalAnnotation.txt: 76
  • Supplementary material 2: 57