Structure	Enzyme/Species	Start	End	Description/Notes	First/Senior Author	Year	DOI	Title
Omega Loop	PDC	177	224	Converted Numbers	Lahiri/Alm	2015	10.1093/jac/dkv004	Selection and molecular characterization of ceftazidime/avibactam-resistant mutants in Pseudomonas aeruginosa strains containing derepressed AmpC
Omega Loop	ADC-68	183	226	Converted Numbers	Jeon/Lee	2014	10.1107/S1399004714019543	"Structure of ADC-68, a novel carbapenem-hydrolyzing class C extended-spectrum ?-lactamase isolated from Acinetobacter baumannii"
Omega Loop	S. marcescens	185	225	No Conversion	Hidiri/Arlet	2005	10.1093/jac/dki025	Resistance to ceftazidime is associated with a S220Y substitution in the omega loop of the AmpC ?-lactamase of a Serratia marcescensclinical isolate
Omega Loop	E. cloacae	189	226	No Conversion	Crichlow/Knox	1999	10.1021/bi9908787	"Structure of the Extended-Spectrum Class C ?-Lactamase of Enterobacter cloacae GC1, a Natural Mutant with a Tandem Tripeptide Insertion,"
Omega Loop	E. cloacae	189	226	Likely from Crichlow/Knox	Raimondi/Nikaido	2001	10.1128/AAC.45.8.2331-2339.2001	Mutation in Serratia marcescens AmpC ?-Lactamase Producing High-Level Resistance to Ceftazidime and Cefpirome
Omega Loop	P99	189	226	No Conversion	Adediran/Pratt	2005	10.1021/bi050136f	The d-Methyl Group in ?-Lactamase Evolution:? Evidence from the Y221G and GC1 Mutants of the Class C ?-Lactamase of Enterobacter cloacae P99
Omega Loop	PDC	198	216	Converted Numbers	Berrazeg/Plésiat	2015	10.1128/AAC.00825-15	Mutations in ?-Lactamase AmpC Increase Resistance of Pseudomonas aeruginosa Isolates to Antipseudomonal Cephalosporins
Omega Loop	TRU-1	200	218	Converted Numbers	Pozzi/Mangani	2018	10.1002/cmdc.201800213	Atomic?Resolution Structure of a Class?C ??Lactamase and Its Complex with Avibactam
Omega Loop	E. cloacae GC1	201	224	Converted Numbers	Nukaga/Knox	2003	10.1074/jbc.M312356200	Hydrolysis of Third-generation Cephalosporins by Class C ?-Lactamases STRUCTURES OF A TRANSITION STATE ANALOG OF CEFOTAXIME IN WILD-TYPE AND EXTENDED SPECTRUM ENZYMES
Omega Loop	Review	*	*	Includes 208-220 (not as boundaries)	Jacoby	2009	10.1128/CMR.00036-08	AmpC ?-Lactamases
Omega Loop	CMY-136	*	*	Includes 199-221 (Not as Boundaries)	Zavala/Naas	2019	10.1021/acsinfecdis.8b00240	"Genetic, Biochemical, and Structural Characterization of CMY-136 ?-Lactamase, a Peculiar CMY-2 Variant"
R2 Loop	FOX-4	286	308	Converted Numbers	Lefurgy/Bonomo	2016	10.1128/AAC.01887-15	Analysis of the Structure and Function of FOX-4 Cephamycinase
R2 Loop	TRU-1	286	308	Converted Numbers	Pozzi/Mangani	2018	10.1002/cmdc.201800213	Atomic?Resolution Structure of a Class?C ??Lactamase and Its Complex with Avibactam
R2 Loop	BER-1	286	310	Converted Numbers	Na/Cha	2016	10.1107/S2059798316011311	Structural basis for the extended substrate spectrum of AmpC BER and structure-guided discovery of the inhibition activity of citrate against the class C ?-lactamases AmpC BER and CMY-10
R2 Loop	MOX-1	287	309	Converted Numbers	Oguri/Shimizu-Ibuka	2014	10.1128/AAC.02363-13	"Crystal Structure of Mox-1, a Unique Plasmid-Mediated Class C ?-Lactamase with Hydrolytic Activity towards Moxalactam"
R2 Loop	FOX-4	288	310	Converted Numbers	Mallo/Bou	2010	10.1093/jac/dkq115	A tripeptide deletion in the R2 loop of the class C ?-lactamase enzyme FOX-4 impairs cefoxitin hydrolysis and slightly increases susceptibility to ?-lactamase inhibitors
R2 Loop	Review	289	303	"Says 307, but diagram only to 303 equiv"	Nordmann/Mammeri	2007	10.2217/17460913.2.3.297	"Extended-spectrum cephalosporinases: structure, detection and epidemiology"
R2 Loop	ADC-68	289	310	Converted Numbers	Jeon/Lee	2014	10.1107/S1399004714019543	"Structure of ADC-68, a novel carbapenem-hydrolyzing class C extended-spectrum ?-lactamase isolated from Acinetobacter baumannii"
R2 Loop	CMY-136	289	307	No Conversion	Zavala/Naas	2019	10.1021/acsinfecdis.8b00240	"Genetic, Biochemical, and Structural Characterization of CMY-136 ?-Lactamase, a Peculiar CMY-2 Variant"
R2 Loop	CMY-37	289	310	Converted Numbers	Ahmed/Shimamoto	2008	10.1016/j.ijantimicag.2008.04.019	"Emergence of a cefepime- and cefpirome-resistant Citrobacter freundii clinical isolate harbouring a novel chromosomally encoded AmpC ?-lactamase, CMY-37"