Journal article

Analysis of OXA-204 carbapenemase-producing Enterobacteriaceae reveals possible endoscopy-associated transmission, France, 2012 to 2014

  • Potron, Anaïs National Reference Centre for Antibiotic Resistance, (division of carbapenemase-producing Enterobacteriaceae), Le Kremlin-Bic?tre, France - Department of Bacteriology, University Hospital of Besançon, Université of Franche-Comté, Besançon, France
  • Bernabeu, Sandrine National Reference Centre for Antibiotic Resistance, (division of carbapenemase-producing Enterobacteriaceae), Le Kremlin-Bic?tre, France - Bacteriology-Hygiene Unit, Assistance Publique/Hôpitaux de Paris, Bic?tre Hospital, Le Kremlin-Bic?tre, France - EA7361 “Structure, Dynamic, Function and Expression of Broad Spectrum beta-Lactamases”, Paris-Sud University, LabEx Lermit, Faculty of Medicine, Le Kremlin-Bic?tre, France - Joint Research Unit EERA “Evolution and Ecology of Resistance to Antibiotics,” Institut Pasteur-APHP-Université Paris-Sud, Paris, France
  • Cuzon, Gaëlle National Reference Centre for Antibiotic Resistance, (division of carbapenemase-producing Enterobacteriaceae), Le Kremlin-Bic?tre, France - Bacteriology-Hygiene Unit, Assistance Publique/Hôpitaux de Paris, Bic?tre Hospital, Le Kremlin-Bic?tre, France - EA7361 “Structure, Dynamic, Function and Expression of Broad Spectrum beta-Lactamases”, Paris-Sud University, LabEx Lermit, Faculty of Medicine, Le Kremlin-Bic?tre, France - Joint Research Unit EERA “Evolution and Ecology of Resistance to Antibiotics,” Institut Pasteur-APHP-Université Paris-Sud, Paris, France
  • Pontiès, Valérie Santé Publique France, The French Public Health Agency, Saint-Maurice, France
  • Blanchard, Hervé Regional Coordinating Centre for Nosocomial Infection Control (C-CLIN Paris Nord), Paris, France.
  • Seringe, Elise Regional Coordinating Centre for Nosocomial Infection Control (C-CLIN Paris Nord), Paris, France.
  • Naas, Thierry National Reference Centre for Antibiotic Resistance, (division of carbapenemase-producing Enterobacteriaceae), Le Kremlin-Bic?tre, France - Bacteriology-Hygiene Unit, Assistance Publique/Hôpitaux de Paris, Bic?tre Hospital, Le Kremlin-Bic?tre, France - EA7361 “Structure, Dynamic, Function and Expression of Broad Spectrum beta-Lactamases”, Paris-Sud University, LabEx Lermit, Faculty of Medicine, Le Kremlin-Bic?tre, France - Joint Research Unit EERA “Evolution and Ecology of Resistance to Antibiotics,” Institut Pasteur-APHP-Université Paris-Sud, Paris, France
  • Nordmann, Patrice Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland - Institut National de la Santé et de la Recherche Médicale (INSERM) European Unit (LEA Paris, IAME, France), University of Fribourg, Switzerland - National Reference Centre for Emerging Antibiotic Resistance, Fribourg, Switzerland - Institute for Microbiology, University hospital and University of Lausanne, Lausanne, Switzerland
  • Dortet, Laurent National Reference Centre for Antibiotic Resistance, (division of carbapenemase-producing Enterobacteriaceae), Le Kremlin-Bic?tre, France - Bacteriology-Hygiene Unit, Assistance Publique/Hôpitaux de Paris, Bic?tre Hospital, Le Kremlin-Bic?tre, France - EA7361 “Structure, Dynamic, Function and Expression of Broad Spectrum beta-Lactamases”, Paris-Sud University, LabEx Lermit, Faculty of Medicine, Le Kremlin-Bic?tre, France - Joint Research Unit EERA “Evolution and Ecology of Resistance to Antibiotics,” Institut Pasteur-APHP-Université Paris-Sud, Paris, France
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    07.12.2017
Published in:
  • Eurosurveillance. - 2017, vol. 22, no. 49, p. 17-00048
English OXA-48-like beta-lactamase producing bacteria are now endemic in several European and Mediterranean countries. Among this carbapenemase family, the OXA-48 and OXA-181 variants predominate, whereas other variants such as OXA-204 are rarely reported. Here, we report the molecular epidemiology of a collection of OXA-204- positive enterobacterial isolates (n = 29) recovered in France between October 2012 and May 2014. This study describes the first outbreak of OXA-204-producing Enterobacteriaceae in Europe, involving 12 isolates of an ST90 Escherichia coli clone and nine isolates of an ST147 Klebsiella pneumoniae clone. All isolates co-produced the cephalosporinase CMY-4, and 60% of them co-produced the extended-spectrum beta-lactamase CTX-M-15. The blaOXA-204 gene was located on a 150-kb IncA/C plasmid, isolated from various enterobacterial species in the same patient, indicating a high conjugative ability of this genetic vehicle.
Faculty
Faculté des sciences et de médecine
Department
Médecine 3ème année
Language
  • English
Classification
Biological sciences
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/306211
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