Potron, Anaïs Bernabeu, Sandrine Cuzon, Gaëlle Pontiès, Valérie Blanchard, Hervé Seringe, Elise Naas, Thierry Nordmann, Patrice Dortet, Laurent 2017-12-07 OXA-48-like beta-lactamase producing bacteria are now endemic in several European and Mediterranean countries. Among this carbapenemase family, the OXA-48 and OXA-181 variants predominate, whereas other variants such as OXA-204 are rarely reported. Here, we report the molecular epidemiology of a collection of OXA-204- positive enterobacterial isolates (n = 29) recovered in France between October 2012 and May 2014. This study describes the first outbreak of OXA-204-producing Enterobacteriaceae in Europe, involving 12 isolates of an ST90 Escherichia coli clone and nine isolates of an ST147 Klebsiella pneumoniae clone. All isolates co-produced the cephalosporinase CMY-4, and 60% of them co-produced the extended-spectrum beta-lactamase CTX-M-15. The blaOXA-204 gene was located on a 150-kb IncA/C plasmid, isolated from various enterobacterial species in the same patient, indicating a high conjugative ability of this genetic vehicle. application/pdf https://folia.unifr.ch/global/documents/306211 https://folia.unifr.ch/documents/306211/files/nor_aoc.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.2807/1560-7917.ES.2017.22.49.17-00048 info:eu-repo/semantics/openAccess License undefined Eurosurveillance. - 2017, vol. 22, no. 49, p. 17-00048 info:eu-repo/classification/udc/57 Analysis of OXA-204 carbapenemase-producing Enterobacteriaceae reveals possible endoscopy-associated transmission, France, 2012 to 2014 http://purl.org/coar/resource_type/c_6501