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Synthesis, characterization and cellular location of cytotoxic constitutional organometallic isomers of rhenium delivered on a cyanocobalmin scaffold

  • Santoro, Giuseppe Department of Chemistry, University of Fribourg, Switzerland
  • Zlateva, Theodora Paul Scherrer Institute, Swiss Light Source, Villigen-PSI, Switzerland
  • Ruggi, Albert Department of Chemistry, University of Fribourg, Switzerland
  • Quaroni, Luca Paul Scherrer Institute, Swiss Light Source, Villigen-PSI, Switzerland
  • Zobi, Fabio Department of Chemistry, University of Fribourg, Switzerland
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    01.04.2015
Published in:
  • Dalton Transactions. - 2015, vol. 44, no. 15, p. 6999–7008
English Constitutional isomers of cyanocobalamin adducts based on a fluorescent rhenium tris-carbonyl diimine complex were prepared, characterized and tested against PC-3 cancer cells. The adducts differ only in the relative binding position of the organometallic species which is either bound at the cyano or the 5′-hydroxo group of vitamin B₁₂. When tested for their cytotoxic potency, the species showed IC₅₀ values in the low μM rage. Upon conjugation to the vitamin an energy transfer process causes an extremely low quantum yield of fluorescence emission, making the conjugates unsuitable for fluorescence imaging. However, by exploiting the vibrational signature of the fac-[Re(CO)₃]⁺ core, their cellular distribution was evaluated via FTIR spectromicroscopy.
Faculty
Faculté des sciences et de médecine
Department
Département de Chimie
Language
  • English
Classification
Chemistry
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/304417
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