Multidrug-resistant Acinetobacter baumannii strains carrying the blaOxA-23 and the blaGES-11 genes in a neonatology center in Tunisia

Charfi-Kessis, Karama; Mansour, Wejdene; Khalifa, Anis Ben Haj; Mastouri, Maha; Nordmann, Patrice; Aouni, Mahjoub; Poirel, Laurent

doi:10.1016/j.micpath.2014.07.003

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Journal article

Multidrug-resistant Acinetobacter baumannii strains carrying the blaOxA-23 and the blaGES-11 genes in a neonatology center in Tunisia

Charfi-Kessis, Karama INSERM U914, South-Paris Medical School, K.-Bicêtre, France - Laboratoire des Maladies Transmissibles et Substances Biologiquement Actives LR99ES27, Faculté de Pharmacie, Monastir, Tunisia
Mansour, Wejdene Laboratoire des Maladies Transmissibles et Substances Biologiquement Actives LR99ES27, Faculté de Pharmacie, Monastir, Tunisia
Khalifa, Anis Ben Haj Laboratoire de Microbiologie, CHU Taher Sfar Mahdia, Tunisia
Mastouri, Maha Laboratoire des Maladies Transmissibles et Substances Biologiquement Actives LR99ES27, Faculté de Pharmacie, Monastir, Tunisia
Nordmann, Patrice INSERM U914, South-Paris Medical School, K.-Bicêtre, France - Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland
Aouni, Mahjoub Laboratoire des Maladies Transmissibles et Substances Biologiquement Actives LR99ES27, Faculté de Pharmacie, Monastir, Tunisia
Poirel, Laurent INSERM U914, South-Paris Medical School, K.-Bicêtre, France - Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland

22.07.2014

Published in:

Microbial Pathogenesis. - 2014, vol. 74, p. 20–24

English Multidrug-resistant and difficult-to-treat Acinetobacter baumannii may be responsible for nosocomial infections. The production of carbapenem-hydrolyzing class D β-lactamases (CHDLs) and extended-spectrum β-lactamase (ESBLs) of the GES type possessing a carbapenemase activity has been increasingly reported worldwide in A. baumannii. The aim of this study was to analyze the resistance mechanisms of two carbapenem resistant A. baumannii clinical isolates recovered in a neonatology center in the center-east of Tunisia.Two carbapenem resistant A. baumannii isolates were recovered. The first isolate co-harbored the bla_GES-11 ESBL gene and the bla_O_xA-23 CHDL gene. Analyses of the genetic location indicated that the bla_GES-11 gene was plasmid located (Gr6). However, the bla_O_xA-23 gene was located on the chromosome. The second strain had only the bla_O_xA-23 CHDL gene, which was plasmid located.This study showed the first description of the GES-type β-lactamase in A. baumannii in Tunisia.

Faculty

Faculté des sciences et de médecine

Department

Médecine 3ème année

Language