Derepressed transfer properties leading to the efficient spread of the plasmid encoding carbapenemase OXA-48

Potron, Anaïs; Poirel, Laurent; Nordmann, Patrice

doi:10.1128/AAC.01344-13

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Journal article

Derepressed transfer properties leading to the efficient spread of the plasmid encoding carbapenemase OXA-48

Potron, Anaïs INSERM U914, Emerging Resistance to Antibiotics, Faculté de Médecine et Université Paris-Sud, K. Bicêtre, France
Poirel, Laurent INSERM U914, Emerging Resistance to Antibiotics, Faculté de Médecine et Université Paris-Sud, K. Bicêtre, France - Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland
Nordmann, Patrice INSERM U914, Emerging Resistance to Antibiotics, Faculté de Médecine et Université Paris-Sud, K. Bicêtre, France - Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland

01.01.2014

Published in:

Antimicrobial Agents and Chemotherapy. - 2013, vol. 58, no. 1, p. 467–471

English The current emergence of the carbapenemase OXA-48 among Enterobacteriaceae is related to the spread of a single IncL/M-type plasmid, pOXA-48a. This plasmid harbors the bla_OXA-48 gene within a composite transposon, Tn1999, which is inserted into the tir gene, encoding a transfer inhibition protein. We showed that the insertion of Tn1999 into the tir gene was involved in a higher transfer frequency of plasmid pOXA-48a. This may likely be the key factor for the successful dissemination of this plasmid.

Faculty

Faculté des sciences et de médecine

Department

Médecine 3ème année

Language