NPR1 modulates cross-talk between salicylate- and jasmonate-dependent defense pathways through a novel function in the cytosol

Spoel, Steven H.; Koornneef, Annemart; Claessens, Susanne M. C.; Korzelius, Jerôme P.; Pelt, Johan A. van; Mueller, Martin J.; Buchala, Antony J.; Métraux, Jean-Pierre; Brown, Rebecca; Kazan, Kemal; Loon, L. C. van; Dong, Xinnian; Pieterse, Corné M. J.

doi:10.1105/tpc.009159

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Journal article

NPR1 modulates cross-talk between salicylate- and jasmonate-dependent defense pathways through a novel function in the cytosol

Spoel, Steven H. Graduate School of Experimental Plant Sciences, Section of Phytopathology, Faculty of Biology, Utrecht University, The Netherlands - Developmental, Cell, and Molecular Biology Group, Department of Biology, Duke University, Durham, North Carolina, USA
Koornneef, Annemart Graduate School of Experimental Plant Sciences, Section of Phytopathology, Faculty of Biology, Utrecht University, The Netherlands
Claessens, Susanne M. C. Graduate School of Experimental Plant Sciences, Section of Phytopathology, Faculty of Biology, Utrecht University, The Netherlands
Korzelius, Jerôme P. Graduate School of Experimental Plant Sciences, Section of Phytopathology, Faculty of Biology, Utrecht University, The Netherlands
Pelt, Johan A. van Graduate School of Experimental Plant Sciences, Section of Phytopathology, Faculty of Biology, Utrecht University, The Netherlands
Mueller, Martin J. Pharmaceutical Biology, Julius-von-Sachs Institute of Biological Sciences, University of Wuerzburg, Germany
Buchala, Antony J. Department of Biology, University of Fribourg, Switzerland
Métraux, Jean-Pierre Department of Biology, University of Fribourg, Switzerland
Brown, Rebecca Cooperative Research Centre for Tropical Plant Pathology, University of Queensland, St. Lucia, Australia
Kazan, Kemal Cooperative Research Centre for Tropical Plant Pathology, University of Queensland, St. Lucia, Australia
Loon, L. C. van Graduate School of Experimental Plant Sciences, Section of Phytopathology, Faculty of Biology, Utrecht University, The Netherlands
Dong, Xinnian Developmental, Cell, and Molecular Biology Group, Department of Biology, Duke University, Durham, North Carolina, USA
Pieterse, Corné M. J. Département de Biologie, Université de Fribourg, Switzerland - Graduate School of Experimental Plant Sciences, Section of Phytopathology, Faculty of Biology, Utrecht University, The Netherlands

21.02.2003

Published in:

The Plant Cell. - 2003, vol. 15, p. 760

English Plant defenses against pathogens and insects are regulated differentially by cross-communicating signal transduction pathways in which salicylic acid (SA) and jasmonic acid (JA) play key roles. In this study, we investigated the molecular mechanism of the antagonistic effect of SA on JA signaling. Arabidopsis plants unable to accumulate SA produced 25-fold higher levels of JA and showed enhanced expression of the JA-responsive genes LOX2, PDF1.2, and VSP in response to infection by Pseudomonas syringae pv tomato DC3000, indicating that in wild-type plants, pathogen-induced SA accumulation is associated with the suppression of JA signaling. Analysis of the Arabidopsis mutant npr1, which is impaired in SA signal transduction, revealed that the antagonistic effect of SA on JA signaling requires the regulatory protein NPR1. Nuclear localization of NPR1, which is essential for SA-mediated defense gene expression, is not required for the suppression of JA signaling, indicating that cross-talk between SA and JA is modulated through a novel function of NPR1 in the cytosol.

Faculty

Faculté des sciences et de médecine

Department

Département de Biologie

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