Evaluation of SuperCAZ/AVI® Medium for Screening Ceftazidime-avibactam Resistant Gram-negative Isolates

Sadek, Mustafa; Poirel, Laurent; Dominguez Pino, Manuel; D'Emidio, Fernando; Pomponio, Stefano; Nordmann, Patrice

doi:10.1016/j.diagmicrobio.2021.115475

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Journal article

Evaluation of SuperCAZ/AVI® Medium for Screening Ceftazidime-avibactam Resistant Gram-negative Isolates

DOKPE

Sadek, Mustafa ORCID Université de Fribourg
Poirel, Laurent ORCID Université de Fribourg
Dominguez Pino, Manuel Université de Fribourg
D'Emidio, Fernando Liofilchem, Roseto degli Abruzzi, Italy
Pomponio, Stefano Liofilchem, Roseto degli Abruzzi, Italy
Nordmann, Patrice ORCID Université de Fribourg

2021

Published in:

Diagnostic Microbiology and Infectious Disease. - Amsterdam : Elsevier B.V.. - 2021, vol. 101, no. 4, p. 1-4

English The industrial version of SuperCAZ/AVI® medium developed for screening CAZ/AVI resistant Gram-negative isolates has been evaluated here using a collection of 87 well-characterized clinical isolates of worldwide origin. In addition, testing was performed by spiking stools with a series of resistant and susceptible isolates. In those conditions, the SuperCAZ/AVI® medium exhibited a sensitivity and specificity of 100 %, down to the lower limit of detection of 101 to 102 CFU/ml. The SuperCAZ/AVI® medium is a sensitive and specific screening medium for detection of CZA-resistant bacteria regardless of their resistance mechanisms.

Faculty

Faculté des sciences et de médecine

Department

Médecine 3ème année

Language