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Eradication of a multidrug-resistant, carbapenemase-producing Klebsiella pneumoniae isolate following oral and intra-rectal therapy with a custom made, lytic bacteriophage preparation

  • Corbellino, Mario III Division of Infectious Diseases, Azienda Socio Sanitaria Territoriale (ASST) Fatebenefratelli Sacco, Milano, Italy
  • Kieffer, Nicolas Medical and Molecular Microbiology, Faculty of Science and Medicine, Institut National de la Santé et de la Recherche Médicale (INSERM) European Unit (IAME, France), University of Fribourg, Fribourg, Switzerland
  • Kutateladze, Mzia G. Eliava Institute of Bacteriophages, Microbiology and Virology, Tbilisi, Georgia
  • Balarjishvili, Nana G. Eliava Institute of Bacteriophages, Microbiology and Virology, Tbilisi, Georgia
  • Leshkasheli, Lika G. Eliava Institute of Bacteriophages, Microbiology and Virology, Tbilisi, Georgia
  • Askilashvili, Lia G. Eliava Institute of Bacteriophages, Microbiology and Virology, Tbilisi, Georgia
  • Tsertsvadze, George G. Eliava Institute of Bacteriophages, Microbiology and Virology, Tbilisi, Georgia
  • Rimoldi, Sara Giordana Division of Microbiology, ASST Fatebenefratelli–Sacco, Milano, Italy
  • Nizharadze, Deia Eliava Phage Therapy Center LLC, Tbilisi, Georgia
  • Hoyle, Naomi Eliava Phage Therapy Center LLC, Tbilisi, Georgia
  • Nadareishvili, Lia Eliava Phage Therapy Center LLC, Tbilisi, Georgia
  • Antinori, Spinello III Division of Infectious Diseases, Azienda Socio Sanitaria Territoriale (ASST) Fatebenefratelli Sacco, Milano, Italy - Luigi Sacco Department of Clinical and Biomedical Sciences, University of Milano, Milano, Italy
  • Pagani, Cristina Division of Microbiology, ASST Fatebenefratelli–Sacco, Milano, Italy
  • Scorza, Daniele Giuseppe Division of Microbiology, ASST Fatebenefratelli–Sacco, Milano, Italy
  • Romanò, Ai Ling Loredana Division of Urology, ASST Fatebenefratelli - Sacco, Milano, Italy
  • Ardizzone, Sandro Luigi Sacco Department of Clinical and Biomedical Sciences, University of Milano, Milano, Italy - Division of Gastroenterology, ASST Fatebenefratelli - Sacco, Milano, Italy
  • Danelli, Piergiorgio Luigi Sacco Department of Clinical and Biomedical Sciences, University of Milano, Milano, Italy - Division of General Surgery, ASST Fatebenefratelli - Sacco, Milano, Italy
  • Gismondo, Maria Rita Division of Microbiology, ASST Fatebenefratelli–Sacco, Milano, Italy - Luigi Sacco Department of Clinical and Biomedical Sciences, University of Milano, Milano, Italy
  • Galli, Massimo III Division of Infectious Diseases, Azienda Socio Sanitaria Territoriale (ASST) Fatebenefratelli Sacco, Milano, Italy - Luigi Sacco Department of Clinical and Biomedical Sciences, University of Milano, Milano, Italy
  • Nordmann, Patrice Medical and Molecular Microbiology, Faculty of Science and Medicine, Institut National de la Santé et de la Recherche Médicale (INSERM) European Unit (IAME, France), University of Fribourg, Fribourg, Switzerland
  • Poirel, Laurent Medical and Molecular Microbiology, Faculty of Science and Medicine, Institut National de la Santé et de la Recherche Médicale (INSERM) European Unit (IAME, France), University of Fribourg, Fribourg, Switzerland
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    15.04.2020
Published in:
  • Clinical Infectious Diseases. - 2020, vol. 70, no. 9, p. 1998–2001
English In July 2017, a patient presented colonization with a multidrug-resistant, carbapenemase (KPC-3)-producing Klebsiella pneumoniae isolate. A custom-made, lytic bacteriophage preparation was administered to the patient in December 2017, with subsequent eradication of the microorganism and without adverse effects.
Faculty
Faculté des sciences et de médecine
Department
Médecine 3ème année
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/308804
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