Journal article

Antimicrobial effects of antipyretics

  • Zimmermann, Petra Department of Paediatrics, The University of Melbourne, Parkville, Australia - Infectious Diseases and Microbiology Research Group, Murdoch Children's Research Institute, Parkville, Australia - Infectious Diseases Unit, The Royal Children's Hospital Melbourne, Parkville, Australia - Department of Medicine, University of Fribourg, Switzerland
  • Curtis, Nigel Department of Paediatrics, The University of Melbourne, Parkville, Australia - Infectious Diseases and Microbiology Research Group, Murdoch Children's Research Institute, Parkville, Australia - Infectious Diseases Unit, The Royal Children's Hospital Melbourne, Parkville, Australia
    01.04.2017
Published in:
  • Antimicrobial Agents and Chemotherapy. - 2017, vol. 61, no. 4
English Antipyretics are some of the most commonly used drugs. Since they are often coadministered with antimicrobial therapy, it is important to understand the interactions between these two classes of drugs. Our review is the first to summarize the antimicrobial effects of antipyretic drugs and the underlying mechanisms involved. Antipyretics can inhibit virus replication, inhibit or promote bacterial or fungal growth, alter the expression of virulence factors, change the surface hydrophobicity of microbes, influence biofilm production, affect the motility, adherence, and metabolism of pathogens, interact with the transport and release of antibiotics by leukocytes, modify the susceptibility of bacteria to antibiotics, and induce or reduce the frequency of mutations leading to antimicrobial resistance. While antipyretics may compromise the efficacy of antimicrobial therapy, they can also be beneficial, for example, in the management of biofilm-associated infections, in reducing virulence factors, in therapy of resistant pathogens, and in inducing synergistic effects. In an era where it is becoming increasingly difficult to find new antimicrobial drugs, targeting virulence factors, enhancing the efficacy of antimicrobial therapy, and reducing resistance may be important strategies.
Faculty
Faculté des sciences et de médecine
Department
Master en médecine
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/308408
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