Journal article

Pfm-like enzymes are a novel family of subclass b2 metallo-β-lactamases from Pseudomonas synxantha belonging to the Pseudomonas fluorescens complex

  • Poirel, Laurent Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland - INSERM European Unit (IAME, France), University of Fribourg, Fribourg, Switzerland - Swiss National Reference Center for Emerging Antibiotic Resistance (NARA), University of Fribourg, Switzerland
  • Palmieri, Mattia Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland - bioMérieux, Data Analytics Unit, La Balme Les Grottes, France
  • Brilhante, Michael Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Switzerland
  • Masseron, Amandine Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland
  • Perreten, Vincent Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Switzerland
  • Nordmann, Patrice Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland - INSERM European Unit (IAME, France), University of Fribourg, Fribourg, Switzerland - Swiss National Reference Center for Emerging Antibiotic Resistance (NARA), University of Fribourg, Switzerland - Institute for Microbiology, University of Lausanne and University Hospital Centre, Lausanne, Switzerland
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    27.01.2020
Published in:
  • Antimicrobial Agents and Chemotherapy. - 2020, vol. 64, no. 2
English A carbapenem-resistant Pseudomonas synxantha isolate recovered from chicken meat produced the novel carbapenemase PFM-1. That subclass B2 metallo-β- lactamase shared 71% amino acid identity with β-lactamase Sfh-1 from Serratia fonticola. The blaPFM-1 gene was chromosomally located and likely acquired. Variants of PFM-1 sharing 90% to 92% amino acid identity were identified in bacterial species belonging to the Pseudomonas fluorescens complex, including Pseudomonas libanensis (PFM-2) and Pseudomonas fluorescens (PFM-3), highlighting that these species constitute reservoirs of PFM-like encoding genes.
Faculty
Faculté des sciences et de médecine
Department
Médecine 3ème année
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/308292
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