Contortamide, a new anti-colon cancer cerebroside and other constituents from Tabernaemontana contorta Stapf (Apocynaceae)
- Ebede, Guy R. Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Cameroon - Department of Chemistry, Faculty of Science and Medicine, University of Fribourg, Switzerland
- Ndongo, Joseph T. Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, Cameroon
- Mbing, Joséphine Ngo Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Cameroon
- Kenfack, Hector C. M. Department of Biochemistry, Faculty of Science, University of Dschang, Cameroon
- Pegnyemb, Dieudonné Emmanuel Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Cameroon
- Bochet, Christian G. Department of Chemistry, Faculty of Science and Medicine, University of Fribourg, Switzerland
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05.07.2019
Published in:
- Natural Product Research. - 2019, p. 1-9
English
A new cerebroside, Contortamide (1) together with nine known compounds spegatrine (2), affinisine (3), Nb-methylaffinisine (4), ursolic acid (5), α-amyrin (6), bauerenol acetate (7), lupeol (8), betulinic acid (9) and β-sitosterolglycoside (10) were isolated from the trunk bark of Tabernaemontana contorta Stapf. The new compound 1 showed significant activity against Caco-2 colon cancer cells with the MTT method. Compounds 1–4 and 6–9 were isolated for the first time from this species.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Chimie
- Language
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- English
- Classification
- Chemistry
- License
- License undefined
- Identifiers
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- RERO DOC 326951
- DOI 10.1080/14786419.2019.1636243
- Persistent URL
- https://folia.unifr.ch/unifr/documents/308060
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