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Contortamide, a new anti-colon cancer cerebroside and other constituents from Tabernaemontana contorta Stapf (Apocynaceae)

  • Ebede, Guy R. Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Cameroon - Department of Chemistry, Faculty of Science and Medicine, University of Fribourg, Switzerland
  • Ndongo, Joseph T. Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, Cameroon
  • Mbing, Joséphine Ngo Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Cameroon
  • Kenfack, Hector C. M. Department of Biochemistry, Faculty of Science, University of Dschang, Cameroon
  • Pegnyemb, Dieudonné Emmanuel Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Cameroon
  • Bochet, Christian G. Department of Chemistry, Faculty of Science and Medicine, University of Fribourg, Switzerland
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    05.07.2019
Published in:
  • Natural Product Research. - 2019, p. 1-9
English A new cerebroside, Contortamide (1) together with nine known compounds spegatrine (2), affinisine (3), Nb-methylaffinisine (4), ursolic acid (5), α-amyrin (6), bauerenol acetate (7), lupeol (8), betulinic acid (9) and β-sitosterolglycoside (10) were isolated from the trunk bark of Tabernaemontana contorta Stapf. The new compound 1 showed significant activity against Caco-2 colon cancer cells with the MTT method. Compounds 1–4 and 6–9 were isolated for the first time from this species.
Faculty
Faculté des sciences et de médecine
Department
Département de Chimie
Language
  • English
Classification
Chemistry
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/308060
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