Journal article
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The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species
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Carmona-Gutierrez, Didac
Institute of Molecular Biosciences, NAWI Graz, University of Graz,Austria
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Zimmermann, Andreas
Institute of Molecular Biosciences, NAWI Graz, University of Graz,Austria - Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Austria
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Kainz, Katharina
Institute of Molecular Biosciences, NAWI Graz, University of Graz,Austria
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Pietrocola, Federico
Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138, Paris, France - Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Center, Villejuif, France. - Université Paris Descartes, Sorbonne Paris Cité, Paris, France - Université Pierre et Marie Curie, Paris, France
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Chen, Guo
Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138, Paris, France - Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Center, Villejuif, France. - Université Paris Descartes, Sorbonne Paris Cité, Paris, France - Université Pierre et Marie Curie, Paris, France
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Maglioni, Silvia
IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany
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Schiavi, Alfonso
IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany
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Nah, Jihoon
Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, USA
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Mertel, Sara
Institute for Biology/Genetics, Freie Universität Berlin, Germany
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Beuschel, Christine B.
Institute for Biology/Genetics, Freie Universität Berlin, Germany
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Castoldi, Francesca
Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138, Paris, France - Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Center, Villejuif, France. - Université Paris Descartes, Sorbonne Paris Cité, Paris, France - Université Pierre et Marie Curie, Paris, France - Sotio a.c, Prague, Czech Republic
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Sica, Valentina
Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138, Paris, France - Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Center, Villejuif, France. - Université Paris Descartes, Sorbonne Paris Cité, Paris, France - Université Pierre et Marie Curie, Paris, France
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Trausinger, Gert
Joanneum Research Forschungsgesellschaft m.b.H., HEALTH, Institute for Biomedicine and Health Sciences, Graz, Austria
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Raml, Reingard
Joanneum Research Forschungsgesellschaft m.b.H., HEALTH, Institute for Biomedicine and Health Sciences, Graz, Austria
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Sommer, Cornelia
Institute of Molecular Biosciences, NAWI Graz, University of Graz,Austria
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Schroeder, Sabrina
Institute of Molecular Biosciences, NAWI Graz, University of Graz,Austria
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Hofer, Sebastian J.
Institute of Molecular Biosciences, NAWI Graz, University of Graz,Austria
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Bauer, Maria A.
Institute of Molecular Biosciences, NAWI Graz, University of Graz,Austria
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Pendl, Tobias
Institute of Molecular Biosciences, NAWI Graz, University of Graz,Austria
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Tadic, Jelena
Institute of Molecular Biosciences, NAWI Graz, University of Graz,Austria
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Dammbrueck, Christopher
Institute of Molecular Biosciences, NAWI Graz, University of Graz,Austria
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Hu, Zehan
Department of Cardiology, Medical University of Graz, Austria
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Ruckenstuhl, Christoph
Institute of Molecular Biosciences, NAWI Graz, University of Graz,Austria
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Eisenberg, Tobias
Institute of Molecular Biosciences, NAWI Graz, University of Graz,Austria
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Durand, Sylvere
Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138, Paris, France - Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Center, Villejuif, France.
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Bossut, Noélie
Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138, Paris, France - Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Center, Villejuif, France.
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Aprahamian, Fanny
Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138, Paris, France - Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Center, Villejuif, France.
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Abdellatif, Mahmoud
Department of Cardiology, Medical University of Graz, Austria
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Sedej, Simon
Department of Cardiology, Medical University of Graz, Austria - BioTechMed Graz, Austria
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Enot, David P.
Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138, Paris, France - Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Center, Villejuif, France.
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Wolinski, Heimo
Institute of Molecular Biosciences, NAWI Graz, University of Graz,Austria
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Dengjel, Jörn
Department of Biology, Université de Fribourg, Switzerland
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Kepp, Oliver
Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138, Paris, France - Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Center, Villejuif, France. - Université Paris Descartes, Sorbonne Paris Cité, Paris, France - Université Pierre et Marie Curie, Paris, France
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Magnes, Christoph
Joanneum Research Forschungsgesellschaft m.b.H., HEALTH, Institute for Biomedicine and Health Sciences, Graz, Austria
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Sinner, Frank
Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Austria - Joanneum Research Forschungsgesellschaft m.b.H., HEALTH, Institute for Biomedicine and Health Sciences, Graz, Austria
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Pieber, Thomas R.
Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Austria - Joanneum Research Forschungsgesellschaft m.b.H., HEALTH, Institute for Biomedicine and Health Sciences, Graz, Austria
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Sadoshima, Junichi
Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, USA
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Ventura, Natascia
IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany - Institute for Clinical Chemistry and Laboratory Diagnostic, Medical Faculty of the Heinrich Heine University, Düsseldorf, Germany
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Sigrist, Stephan J.
Institute for Biology/Genetics, Freie Universität Berlin, Germany - NeuroCure, Charité, Berlin, Germany
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Kroemer, Guido
Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138, Paris, France - Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Center, Villejuif, France. - Université Paris Descartes, Sorbonne Paris Cité, Paris, France - Université Pierre et Marie Curie, Paris, France - Pôle de Biologie, Hôpital Européen Georges Pompidou, Paris, France - Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden
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Madeo, Frank
Institute of Molecular Biosciences, NAWI Graz, University of Graz,Austria - BioTechMed Graz, Austria
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Published in:
- Nature Communications. - 2019, vol. 10, no. 1, p. 651
English
Ageing constitutes the most important risk factor for all major chronic ailments, including malignant, cardiovascular and neurodegenerative diseases. However, behavioural and pharmacological interventions with feasible potential to promote health upon ageing remain rare. Here we report the identification of the flavonoid 4,4′- dimethoxychalcone (DMC) as a natural compound with anti-ageing properties. External DMC administration extends the lifespan of yeast, worms and flies, decelerates senescence of human cell cultures, and protects mice from prolonged myocardial ischaemia. Concomitantly, DMC induces autophagy, which is essential for its cytoprotective effects from yeast to mice. This pro-autophagic response induces a conserved systemic change in metabolism, operates independently of TORC1 signalling and depends on specific GATA transcription factors. Notably, we identify DMC in the plant Angelica keiskei koidzumi, to which longevity- and health-promoting effects are ascribed in Asian traditional medicine. In summary, we have identified and mechanistically characterised the conserved longevity-promoting effects of a natural anti-ageing drug.
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Faculty
- Faculté des sciences et de médecine
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Department
- Département de Biologie
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Language
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Classification
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Biological sciences
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License
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License undefined
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/307747
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