Journal article

Rapid detection of fosfomycin resistance in Escherichia coli

  • Nordmann, Patrice Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology Faculty of Science and Medicine, University of Fribourg, Switzerland - Swiss National Reference Center for Emerging Antibiotic Resistance (NARA), University of Fribourg, Switzerland - INSERM European Unit (LEA, IAME), University of Fribourg, Switzerland - University Hospital Center and University of Lausanne, Switzerland
  • Poirel, Laurent Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology Faculty of Science and Medicine, University of Fribourg, Switzerland - Swiss National Reference Center for Emerging Antibiotic Resistance (NARA), University of Fribourg, Switzerland - INSERM European Unit (LEA, IAME), University of Fribourg, Switzerland
  • Mueller, Linda Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology Faculty of Science and Medicine, University of Fribourg, Switzerland - Swiss National Reference Center for Emerging Antibiotic Resistance (NARA), University of Fribourg, Switzerland
    01.01.2019
Published in:
  • Journal of Clinical Microbiology. - 2019, vol. 57, no. 1, p. e01531-18
English The rapid fosfomycin/Escherichia coli NP test was developed to detect fosfomycin resistance in E. coli isolates. The test is based on glucose metabolization and the detection of bacterial growth in the presence of fosfomycin at 40 µg/ml. Bacterial growth is visually detectable by an orange-to-yellow color change of red phenol, a pH indicator. A total of 100 E. coli isolates, among which 22 were fosfomycin resistant, were used to evaluate the test performance. The sensitivity and specificity of the test were 100% and 98.7%, respectively. This new test is user friendly, sensitive and specific, and its results are obtained in 1 h 30 min.
Faculty
Faculté des sciences et de médecine
Department
Médecine 3ème année
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/307623
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