Acquisition of extended-spectrum β-lactamase GES-6 leading to resistance to ceftolozane-tazobactam combination in Pseudomonas aeruginosa
- Poirel, Laurent Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Switzerland - INSERM European Unit (LEA), IAME, Paris, France - Swiss National Reference Center for Emerging Antibiotic Resistance, Fribourg, Switzerland
- Ortiz de la Rosa, José Manuel Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Switzerland - INSERM European Unit (LEA), IAME, Paris, France
- Kieffer, Nicolas Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Switzerland - Swiss National Reference Center for Emerging Antibiotic Resistance, Fribourg, Switzerland
- Dubois, Véronique Laboratory of Bacteriology, Bordeaux University Hospital, Bordeaux, France - CNRS UMR5234, University of Bordeaux, France
- Jayol, Aurélie Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Switzerland - INSERM European Unit (LEA), IAME, Paris, France - Swiss National Reference Center for Emerging Antibiotic Resistance, Fribourg, Switzerland - Laboratory of Microbiology, Hospital Yverdon, Yverdon-les-Bains, Switzerland
- Nordmann, Patrice Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Switzerland - INSERM European Unit (LEA), IAME, Paris, France - Swiss National Reference Center for Emerging Antibiotic Resistance, Fribourg, Switzerland
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01.01.2019
Published in:
- Antimicrobial Agents and Chemotherapy. - 2019, vol. 63, no. 1, p. e01809-18
English
A clinical Pseudomonas aeruginosa isolate resistant to all β-lactams, including ceftolozane-tazobactam and carbapenems, was recovered. It belonged to sequence type 235 and produced the extended-spectrum β-lactamase (ESBL) GES-6 differing from GES-1 by two amino acid substitutions (E104K and G170S). GES-6 possessed an increased hydrolytic activity toward carbapenems and to ceftolozane and a decreased susceptibility to β-lactamase inhibitors compared to GES-1, except for avibactam. We show here that resistance to ceftolozane-tazobactam may occur through acquisition of a specific ESBL in P. aeruginosa but that ceftazidime-avibactam combination remains an effective alternative.
- Faculty
- Faculté des sciences et de médecine
- Department
- Médecine 3ème année
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 324128
- DOI 10.1128/AAC.01809-18
- Persistent URL
- https://folia.unifr.ch/unifr/documents/307569
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