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Stress impacts the regulation neuropeptides in the rat hippocampus and prefrontal cortex

  • Li, Wenxue Department of Medicine, University of Fribourg, Switzerland
  • Papilloud, Aurelie Laboratory of Behavioral Genetics, Brain Mind Institute, School of Life Science, Ecole Polytechnique Federale de Lausanne, Switzerland
  • Lozano-Montes, Laura Department of Medicine, University of Fribourg, Switzerland
  • Zhao, Nan Division of Biological Technology, Chinese Academy of Science, Dalian Institute of Chemical Physics, Dalian, China
  • Ye, Xueting Division of Biological Technology, Chinese Academy of Science, Dalian Institute of Chemical Physics, Dalian, China
  • Zhang, Xiaozhe Division of Biological Technology, Chinese Academy of Science, Dalian Institute of Chemical Physics, Dalian, China
  • Sandi, Carmen Laboratory of Behavioral Genetics, Brain Mind Institute, School of Life Science, Ecole Polytechnique Federale de Lausanne, Switzerland
  • Rainer, Gregor Department of Medicine, University of Fribourg, Switzerland
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    01.04.2018
Published in:
  • PROTEOMICS. - 2018, vol. 18, no. 7, p. 1700408
English Adverse life experiences increase the lifetime risk to several stress‐related psychopathologies, such as anxiety or depressive‐like symptoms following stress in adulthood. However, the neurochemical modulations triggered by stress have not been fully characterized. Neuropeptides play an important role as signaling molecules that contribute to physiological regulation and have been linked to neurological and psychiatric diseases. However, little is known about the influence of stress on neuropeptide regulation in the brain. Here, we have performed an exploratory study of how neuropeptide expression at adulthood is modulated by experiencing a period of multiple stressful experiences. We have targeted hippocampus and prefrontal cortex (PFC) brain areas, which have previously been shown to be modulated by stressors, employing a targeted liquid chromatography‐mass spectrometry (LC‐MS) based approach that permits broad peptide coverage with high sensitivity. We found that in the hippocampus, Met‐enkephalin, Met‐enkephalin‐Arg‐Phe, and Met‐enkephalin‐Arg‐ Gly‐Leu were upregulated, while Leu‐enkephalin and Little SAAS were downregulated after stress. In the PFC area, Met‐enkephalin‐Arg‐Phe, Met‐enkephalin‐Arg‐Gly‐Leu, peptide PHI‐27, somatostatin‐28 (AA1‐12), and Little SAAS were all downregulated. This systematic evaluation of neuropeptide alterations in the hippocampus and PFC suggests that stressors impact neuropeptides and that neuropeptide regulation is brain‐area specific. These findings suggest several potential peptide candidates, which warrant further investigations in terms of correlation with depression‐associated behaviors.
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/306603
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