Ceftazidime/avibactam alone or in combination with aztreonam against colistin-resistant and carbapenemase-producing Klebsiella pneumoniae
- Jayol, Aurélie Emerging Antibiotic Resistance Unit, Medical and Molecular, Microbiology, Department of Medicine, University of Fribourg, Switzerland
- Nordmann, Patrice Emerging Antibiotic Resistance Unit, Medical and Molecular, Microbiology, Department of Medicine, University of Fribourg, Switzerland - University of Lausanne and University Hospital Center, Lausanne, Switzerland
- Poirel, Laurent Emerging Antibiotic Resistance Unit, Medical and Molecular, Microbiology, Department of Medicine, University of Fribourg, Switzerland
- Dubois, Véronique Laboratory of Bacteriology, University Hospital of Bordeaux, Bordeaux, France - CNRS UMR5234, University of Bordeaux, Bordeaux, France
-
2017
Published in:
- Journal of Antimicrobial Chemotherapy. - 2018, vol. 73, no. 2, p. 542-544
English
The spread of carbapenemase-producing Klebsiella pneumoniae is a major public health concern since such isolates are basically resistant to most available antibiotics, including β-lactams, fluoroquinolones and aminoglycosides.1 Infections due to carbapenemase-producing K. pneumoniae are therefore commonly treated with a regimen containing colistin.1 However, acquired resistance to colistin now occurs frequently and has few therapeutic options.2 Outbreaks with colistin-resistant and carbapenemase-producing K. pneumoniae isolates have been reported worldwide2 and mortality rates are high owing to limited treatment options.3...Recently, a new therapeutic option, namely ceftazidime/avibactam, combining a broad-spectrum cephalosporin and a novel β-lactamase inhibitor, has been marketed. The addition of avibactam expands the spectrum of activity of ceftazidime to many MDR Enterobacteriaceae including producers of ESBLs and carbapenemases.4...
- Faculty
- Faculté des sciences et de médecine
- Department
- Médecine 3ème année
- Language
-
- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
-
- RERO DOC 306278
- DOI 10.1093/jac/dkx393
- Persistent URL
- https://folia.unifr.ch/unifr/documents/306213
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