Journal article

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Ceftazidime/avibactam alone or in combination with aztreonam against colistin-resistant and carbapenemase-producing Klebsiella pneumoniae

  • Jayol, Aurélie Emerging Antibiotic Resistance Unit, Medical and Molecular, Microbiology, Department of Medicine, University of Fribourg, Switzerland
  • Nordmann, Patrice Emerging Antibiotic Resistance Unit, Medical and Molecular, Microbiology, Department of Medicine, University of Fribourg, Switzerland - University of Lausanne and University Hospital Center, Lausanne, Switzerland
  • Poirel, Laurent Emerging Antibiotic Resistance Unit, Medical and Molecular, Microbiology, Department of Medicine, University of Fribourg, Switzerland
  • Dubois, Véronique Laboratory of Bacteriology, University Hospital of Bordeaux, Bordeaux, France - CNRS UMR5234, University of Bordeaux, Bordeaux, France
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    2017
Published in:
  • Journal of Antimicrobial Chemotherapy. - 2017
English The spread of carbapenemase-producing Klebsiella pneumoniae is a major public health concern since such isolates are basically resistant to most available antibiotics, including β-lactams, fluoroquinolones and aminoglycosides.1 Infections due to carbapenemase-producing K. pneumoniae are therefore commonly treated with a regimen containing colistin.1 However, acquired resistance to colistin now occurs frequently and has few therapeutic options.2 Outbreaks with colistin-resistant and carbapenemase-producing K. pneumoniae isolates have been reported worldwide2 and mortality rates are high owing to limited treatment options.3...Recently, a new therapeutic option, namely ceftazidime/avibactam, combining a broad-spectrum cephalosporin and a novel β-lactamase inhibitor, has been marketed. The addition of avibactam expands the spectrum of activity of ceftazidime to many MDR Enterobacteriaceae including producers of ESBLs and carbapenemases.4...
Faculty
Faculté des sciences et de médecine
Department
Médecine 3ème année
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/306213
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