Monomeric and dimeric oxidomolybdenum(V and VI) complexes, cytotoxicity, and DNA interaction studies: molybdenum assisted C═N bond cleavage of salophen ligands

Majumder, Sudarshana; Pasayat, Sagarika; Panda, Alok K.; Dash, Subhashree P.; Roy, Satabdi; Biswas, Ashis; Varma, Mokshada E.; Joshi, Bimba N.; Garribba, Eugenio; Kausar, Chahat; Samir Kumar Patra; Kaminsky, Werner; Crochet, Aurélien; Dinda, Rupam

doi:10.1021/acs.inorgchem.7b01578

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Monomeric and dimeric oxidomolybdenum(V and VI) complexes, cytotoxicity, and DNA interaction studies: molybdenum assisted C═N bond cleavage of salophen ligands

Majumder, Sudarshana Department of Chemistry, National Institute of Technology, Rourkela, Odisha, India
Pasayat, Sagarika Department of Chemistry, National Institute of Technology, Rourkela, Odisha, India
Panda, Alok K. School of Basic Sciences, Indian Institute of Technology Bhubaneswar, Odisha, India
Dash, Subhashree P. Department of Chemistry, National Institute of Technology, Rourkela, Odisha, India - Department of Basic Sciences, Paralamaharaja Engineering College, Sitalapalli, Brahmapur, Odisha, India
Roy, Satabdi Department of Chemistry, National Institute of Technology, Rourkela, Odisha, India
Biswas, Ashis School of Basic Sciences, Indian Institute of Technology Bhubaneswar, Odisha, India
Varma, Mokshada E. Bioprospecting Group, Agharkar Research Institute, G.G. Agharkar Road, Pun, India
Joshi, Bimba N. Bioprospecting Group, Agharkar Research Institute, G.G. Agharkar Road, Pun, India
Garribba, Eugenio Dipartimento di Chimica e Farmacia, Universit? di Sassari, Italy
Kausar, Chahat Department of Life Science, National Institute of Technology, Rourkela, Odisha, India
Samir Kumar Patra Department of Life Science, National Institute of Technology, Rourkela, Odisha, India
Kaminsky, Werner Department of Chemistry, University of Washington, Box 351700, Seattle, Washington, United States
Crochet, Aurélien Department of Chemistry, Fribourg Center for Nanomaterials, University of Fribourg, Switzerland
Dinda, Rupam Department of Chemistry, National Institute of Technology, Rourkela, Odisha, India - Department of Chemistry, University of Washington, Box 351700, Seattle, Washington, United States

18.09.2017

Published in:

Inorganic Chemistry. - 2017, vol. 56, no. 18, p. 11190–11210

English Four novel dimeric bis-μ-imido bridged metal–metal bonded oxidomolybdenum(V) complexes [MoV2O2L′21–4] (1–4) (where L′1–4 are rearranged ligands formed in situ from H2L1–4) and a new mononuclear dioxidomolybdenum(VI) complex [MoVIO2L5] (5) synthesized from salen type N2O2 ligands are reported. This rare series of imido- bridged complexes (1–4) have been furnished from rearranged H3L′1–4 ligands, containing an aromatic diimine (o-phenylenediamine) “linker”, where Mo assisted hydrolysis followed by −C═N bond cleavage of one of the arms of the ligand H2L1–4 took place. A monomeric molybdenum(V) intermediate species [MoVO(HL′1–4)(OEt)] (Id1–4) was generated in situ. The concomitant deprotonation and dimerization of two molybdenum(V) intermediate species (Id1–4) ultimately resulted in the formation of a bis-μ-imido bridge between the two molybdenum centers of [MoV2O2L′21–4] (1–4). The mechanism of formation of 1–4 has been discussed, and one of the rare intermediate monomeric molybdenum(V) species Id4 has been isolated in the solid state and characterized. The monomeric dioxidomolybdenum(VI) complex [MoVIO2L5] (5) was prepared from the ligand H2L5 where the aromatic “linker” was replaced by an aliphatic diimine (1,2-diaminopropane). All the ligands and complexes have been characterized by elemental analysis, IR, UV–vis spectroscopy, NMR, ESI- MS, and cyclic voltammetry, and the structural features of 1, 2, 4, and 5 have been solved by X-ray crystallography. The DNA binding and cleavage activity of 1–5 have been explored. The complexes interact with CT-DNA by the groove binding mode, and the binding constants range between 103 and 104 M–1. Fairly good photoinduced cleavage of pUC19 supercoiled plasmid DNA was exhibited by all the complexes, with 4 showing the most promising photoinduced DNA cleavage activity of ∼93%. Moreover, in vitro cytotoxic activity of all the complexes was evaluated by MTT assay, which reveals that the complexes induce cell death in MCF-7 (human breast adenocarcinoma) and HCT-15 (colon cancer) cell lines.

Faculty

Faculté des sciences et de médecine

Department

Département de Chimie

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