Journal article

Polymyxins: antibacterial activity, susceptibility testing, and resistance mechanisms encoded by plasmids or chromosomes

  • Poirel, Laurent Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Switzerland - French INSERM European Unit, University of Fribourg (LEA-IAME), Fribourg, Switzerland - National Reference Center for Emerging Antibiotic Resistance, Fribourg, Switzerland
  • Jayol, Aurélie Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Switzerland - French INSERM European Unit, University of Fribourg (LEA-IAME), Fribourg, Switzerland - National Reference Center for Emerging Antibiotic Resistance, Fribourg, Switzerland
  • Nordmann, Patrice Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Switzerland - French INSERM European Unit, University of Fribourg (LEA-IAME), Fribourg, Switzerland - National Reference Center for Emerging Antibiotic Resistance, Fribourg, Switzerland - University of Lausanne and University Hospital Center, Lausanne, Switzerland
    04.01.2017
Published in:
  • Clinical Microbiology Reviews. - 2017, vol. 30, no. 2, p. 557–596
English Polymyxins are well-established antibiotics that have recently regained significant interest as a consequence of the increasing incidence of infections due to multidrug- resistant Gram-negative bacteria. Colistin and polymyxin B are being seriously reconsidered as last-resort antibiotics in many areas where multidrug resistance is observed in clinical medicine. In parallel, the heavy use of polymyxins in veterinary medicine is currently being reconsidered due to increased reports of polymyxin- resistant bacteria. Susceptibility testing is challenging with polymyxins, and currently available techniques are presented here. Genotypic and phenotypic methods that provide relevant information for diagnostic laboratories are presented. This review also presents recent works in relation to recently identified mechanisms of polymyxin resistance, including chromosomally encoded resistance traits as well as the recently identified plasmid-encoded polymyxin resistance determinant MCR-1. Epidemiological features summarizing the current knowledge in that field are presented.
Faculty
Faculté des sciences et de médecine
Department
Médecine 3ème année
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/305507
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