In-vitro study of ISApl1-mediated mobilization of the colistin resistance gene mcr-1
- Poirel, Laurent Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland - French INSERM European Unit, University of Fribourg (LEA-IAME), Fribourg, Switzerland - National Reference Center for Emerging Antibiotic Resistance (Switzerland)
- Kieffer, Nicolas Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland - French INSERM European Unit, University of Fribourg (LEA-IAME), Fribourg, Switzerland - National Reference Center for Emerging Antibiotic Resistance (Switzerland)
- Nordmann, Patrice Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland - French INSERM European Unit, University of Fribourg (LEA-IAME), Fribourg, Switzerland - National Reference Center for Emerging Antibiotic Resistance (Switzerland) - University of Lausanne and University hospital Center, Lausanne, Switzerland
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17.04.2017
Published in:
- Antimicrobial Agents and Chemotherapy. - 2017, p. AAC.00127-17
English
The plasmid-mediated mcr-1 gene encodes a phosphoethanolamine transferase conferring resistance to polymyxins. The mcr-1 gene is associated with insertion sequence ISApl1 (IS30 family). In-vitro mobilization assays demonstrated the functionality of the composite transposon structure ISApl1-mcr-1-ISApl1. Transposition generated a 2-bp duplication and occurred in AT-rich DNA regions. This is the first report demonstrating the mobility of the mcr-1 gene by transposition.
- Faculty
- Faculté des sciences et de médecine
- Department
- Médecine 3ème année
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 288694
- DOI 10.1128/AAC.00127-17
- Persistent URL
- https://folia.unifr.ch/unifr/documents/305498
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