Dietary spermidine for lowering high blood pressure

Eisenberg, Tobias; Abdellatif, Mahmoud; Zimmermann, Andreas; Schroeder, Sabrina; Pendl, Tobias; Harger, Alexandra; Stekovic, Slaven; Schipke, Julia; Magnes, Christoph; Schmidt, Albrecht; Ruckenstuhl, Christoph; Dammbrueck, Christopher; Gross, Angelina S.; Herbst, Viktoria; Carmona-Gutierrez, Didac; Pietrocola, Federico; Pieber, Thomas R.; Sigrist, Stephan J.; Linke, Wolfgang A.; Mühlfeld, Christian; Sadoshima, Junichi; Dengjel, Jörn; Kiechl, Stefan; Kroemer, Guido; Sedej, Simon; Madeo, Frank

doi:10.1080/15548627.2017.1280225

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Journal article

Dietary spermidine for lowering high blood pressure

Eisenberg, Tobias Institute of Molecular Biosciences, NAWI Graz, University of Graz, Austria - BioTechMed Graz, Austria
Abdellatif, Mahmoud Department of Cardiology, Medical University of Graz, Austria
Zimmermann, Andreas Institute of Molecular Biosciences, NAWI Graz, University of Graz, Austria
Schroeder, Sabrina Institute of Molecular Biosciences, NAWI Graz, University of Graz, Austria
Pendl, Tobias Institute of Molecular Biosciences, NAWI Graz, University of Graz, Austria
Harger, Alexandra Institute of Molecular Biosciences, NAWI Graz, University of Graz, Austria - Department of Internal Medicine, Medical University of Graz, Austria
Stekovic, Slaven Institute of Molecular Biosciences, NAWI Graz, University of Graz, Austria
Schipke, Julia Institute of Functional and Applied Anatomy, Hannover Medical School, Germany - Cluster of Excellence REBIRTH, Hannover, Germany
Magnes, Christoph Joanneum Research Forschungsgesellschaft m.b.H., HEALTH, Graz, Austria
Schmidt, Albrecht Department of Cardiology, Medical University of Graz, Austria
Ruckenstuhl, Christoph Institute of Molecular Biosciences, NAWI Graz, University of Graz, Austria
Dammbrueck, Christopher Institute of Molecular Biosciences, NAWI Graz, University of Graz, Austria
Gross, Angelina S. Institute of Molecular Biosciences, NAWI Graz, University of Graz, Austria
Herbst, Viktoria Department of Cardiology, Medical University of Graz, Austria
Carmona-Gutierrez, Didac Institute of Molecular Biosciences, NAWI Graz, University of Graz, Austria
Pietrocola, Federico Equipe 11 Labellis et Ligue Contre le Cancer, Centre de Recherche des Cordeliers, Paris, France - Cell Biology and Metabolomics Platforms, Gustave Roussy Comprehensive Cancer Center, Villejuif, France - INSERM, U1138, Paris, France - Université Paris Descartes, Sorbonne Paris Cité, France – Université Pierre et Marie Curie, Paris, France
Pieber, Thomas R. BioTechMed Graz, Austria - Department of Internal Medicine, Medical University of Graz, Austria - Joanneum Research Forschungsgesellschaft m.b.H., HEALTH, Graz, Austria
Sigrist, Stephan J. Institute for Biology, Freie Universität Berlin, Germany - NeuroCure, Charité, Berlin, Germany
Linke, Wolfgang A. Department of Cardiovascular Physiology, Ruhr University Bochum, Germany
Mühlfeld, Christian Institute of Functional and Applied Anatomy, Hannover Medical School, Germany - Cluster of Excellence REBIRTH, Hannover, Germany
Sadoshima, Junichi Department of Cell Biology and Molecular Medicine, Rutgers–New Jersey Medical School, Newark, NJ, USA
Dengjel, Jörn FRIAS Freiburg Institute for Advanced Studies, Department of Dermatology, Medical Center, University of Freiburg, Germany - Department of Biology, University of Fribourg, Switzerland
Kiechl, Stefan Department of Neurology, Medical University of Innsbruck, Austria
Kroemer, Guido Equipe 11 Labellis et Ligue Contre le Cancer, Centre de Recherche des Cordeliers, Paris, France - Cell Biology and Metabolomics Platforms, Gustave Roussy Comprehensive Cancer Center, Villejuif, France - INSERM, U1138, Paris, France - Université Paris Descartes, Sorbonne Paris Cité, France - Universit Pierre et Marie Curie, Paris, France - Pôle de Biologie, Hôpital Européen Georges Pompidou, Paris, France - Karolinska Institute, Department of Women’s and Children’s Health, Karolinska University Hospital, Stockholm, Sweden
Sedej, Simon BioTechMed Graz, Austria - Department of Cardiology, Medical University of Graz, Austria
Madeo, Frank Institute of Molecular Biosciences, NAWI Graz, University of Graz, Austria

24.01.2017

Published in:

Autophagy. - 2017, vol. 13, no. 4, p. 767-769

English Loss of cardiac macroautophagy/autophagy impairs heart function, and evidence accumulates that an increased autophagic flux may protect against cardiovascular disease. We therefore tested the protective capacity of the natural autophagy inducer spermidine in animal models of aging and hypertension, which both represent major risk factors for the development of cardiovascular disease. Dietary spermidine elicits cardioprotective effects in aged mice through enhancing cardiac autophagy and mitophagy. In salt-sensitive rats, spermidine supplementation also delays the development of hypertensive heart disease, coinciding with reduced arterial blood pressure. The high blood pressure-lowering effect likely results from improved global arginine bioavailability and protection from hypertension-associated renal damage. The polyamine spermidine is naturally present in human diets, though to a varying amount depending on food type and preparation. In humans, high dietary spermidine intake correlates with reduced blood pressure and decreased risk of cardiovascular disease and related death. Altogether, spermidine represents a cardio- and vascular- protective autophagy inducer that can be readily integrated in common diets.

Faculty

Faculté des sciences et de médecine

Department

Département de Biologie

Language