Clonal distribution of multidrug-resistant Enterobacter cloacae

Girlich, Delphine; Poirel, Laurent; Nordmann, Patrice

doi:10.1016/j.diagmicrobio.2015.01.003

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Journal article

Clonal distribution of multidrug-resistant Enterobacter cloacae

Girlich, Delphine INSERM U914 “Emerging Resistance to Antibiotics”, K.-Bicêtre, France
Poirel, Laurent INSERM U914 “Emerging Resistance to Antibiotics”, K.-Bicêtre, France - Medical and Molecular Microbiology, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland
Nordmann, Patrice INSERM U914 “Emerging Resistance to Antibiotics”, K.-Bicêtre, France - Medical and Molecular Microbiology, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland - Hôpital Cantonal, Fribourg, Switzerland

2015

Published in:

Diagnostic Microbiology and Infectious Disease. - 2015, vol. 81, no. 4, p. 264–268

English A multilocus sequence typing (MLST) scheme including 7 housekeeping genes was used to evaluate whether the current spread of multidrug-resistant Enterobacter cloacae isolates worldwide might be associated to specific successful clones. Fifty E. cloacae clinical isolates of worldwide origin, with various β-lactamase content, and recovered at different periods of time were studied. Forty-four sequence types were identified, highlighting a high clonal diversity with 3 main lineages. This study revealed that a precise identification of the isolates by sequencing of the chromosomal ampC gene of E. cloacae would provide a significant added value to improve the reliability of the MLST scheme.

Faculty

Faculté des sciences et de médecine

Department

Médecine 3ème année

Language