New Delhi metallo-β-lactamase-producing Acinetobacter baumannii : a novel paradigm for spreading antibiotic resistance genes
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Bonnin, Rémy A.
INSERM U914, Emerging Resistance to Antibiotics, K. Bicêtre, France
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Poirel, Laurent
INSERM U914, Emerging Resistance to Antibiotics, K. Bicêtre, France
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Nordmann, Patrice
INSERM U914, Emerging Resistance to Antibiotics, K. Bicêtre, France - Medical & Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland
Published in:
- Future Microbiology. - 2013, vol. 9, no. 1, p. 33–41
English
The impact of carbapenemase production among clinically significant Gram-negative rods is becoming a major medical issue. To date, Acinetobacter baumannii has been considered as a final recipient of carbapenemase genes (imipenemase, Verona metallo-β-lactamase, Guiana extended-spectrum β-lactamase and Klebsiella pneumonia carbapenemase types) from Enterobacteriaceae and Pseudomonas aeruginosa. However, recent findings regarding the spread of the blaNDM carbapenemase genes revealed that A. baumannii likely acts as a source of emerging antibiotic resistance genes. The analysis of genetic structure surrounding the blaNDM-1 gene revealed that the genetic structure (Tn125) responsible for its dissemination most probably originates from Acinetobacter. Moreover, analysis of the blaNDM-1 gene itself demonstrated that it might be constructed in Acinetobacter through a recombination event with another resistance gene found in A. baumannii (aphA6). This novel paradigm highlights a novel and unexpected role played by A. baumannii.
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Faculty
- Faculté des sciences et de médecine
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Department
- Médecine 3ème année
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Language
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Classification
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Medicine
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License
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License undefined
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/303598
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