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Journal article

New Delhi metallo-β-lactamase-producing Acinetobacter baumannii : a novel paradigm for spreading antibiotic resistance genes

  • Bonnin, Rémy A. INSERM U914, Emerging Resistance to Antibiotics, K. Bicêtre, France
  • Poirel, Laurent INSERM U914, Emerging Resistance to Antibiotics, K. Bicêtre, France
  • Nordmann, Patrice INSERM U914, Emerging Resistance to Antibiotics, K. Bicêtre, France - Medical & Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland
    2014
Published in:
  • Future Microbiology. - 2013, vol. 9, no. 1, p. 33–41
English The impact of carbapenemase production among clinically significant Gram-negative rods is becoming a major medical issue. To date, Acinetobacter baumannii has been considered as a final recipient of carbapenemase genes (imipenemase, Verona metallo-β-lactamase, Guiana extended-spectrum β-lactamase and Klebsiella pneumonia carbapenemase types) from Enterobacteriaceae and Pseudomonas aeruginosa. However, recent findings regarding the spread of the blaNDM carbapenemase genes revealed that A. baumannii likely acts as a source of emerging antibiotic resistance genes. The analysis of genetic structure surrounding the blaNDM-1 gene revealed that the genetic structure (Tn125) responsible for its dissemination most probably originates from Acinetobacter. Moreover, analysis of the blaNDM-1 gene itself demonstrated that it might be constructed in Acinetobacter through a recombination event with another resistance gene found in A. baumannii (aphA6). This novel paradigm highlights a novel and unexpected role played by A. baumannii.
Faculty
Faculté des sciences et de médecine
Department
Médecine 3ème année
Language
  • English
Classification
Medicine
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/303598
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