Plasma-functionalized electrospun matrix for biograft development and cardiac function stabilization

Guex, Anne Géraldine; Frobert, A.; Valentin, Jeremy; Fortunato, G.; Hegemann, D.; Cook, Stéphane; Carrel, Thierry P.; Tevaearai, H.T.; Giraud, Marie-Noëlle

doi:10.1016/j.actbio.2014.01.006

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Plasma-functionalized electrospun matrix for biograft development and cardiac function stabilization

Guex, Anne Géraldine Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, Switzerland - Department of Cardiovascular Surgery, University Hospital and University of Bern, Switzerland - Graduate School for Cellular and Biomedical Sciences, University of Bern, Switzerland
Frobert, A. Cardiology, Department of Medicine, University of Fribourg, Switzerland
Valentin, Jeremy Cardiology, Department of Medicine, University of Fribourg, Switzerland
Fortunato, G. Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, Switzerland
Hegemann, D. Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, Switzerland
Cook, Stéphane Cardiology, Department of Medicine, University of Fribourg, Switzerland
Carrel, Thierry P. Department of Cardiovascular Surgery, University Hospital and University of Bern, Switzerland
Tevaearai, H.T. Department of Cardiovascular Surgery, University Hospital and University of Bern, Switzerland
Giraud, Marie-Noëlle Cardiology, Department of Medicine, University of Fribourg, Switzerland

14.02.2014

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Acta Biomaterialia. - 2014, vol. 10, no. 7, p. 2996–3006

English Cardiac tissue engineering approaches can deliver large numbers of cells to the damaged myocardium and have thus increasingly been considered as a possible curative treatment to counteract the high prevalence of progressive heart failure after myocardial infarction (MI). Optimal scaffold architecture and mechanical and chemical properties, as well as immune- and bio-compatibility, need to be addressed. We demonstrated that radio-frequency plasma surface functionalized electrospun poly(ɛ-caprolactone) (PCL) fibres provide a suitable matrix for bone-marrow-derived mesenchymal stem cell (MSC) cardiac implantation. Using a rat model of chronic MI, we showed that MSC-seeded plasma-coated PCL grafts stabilized cardiac function and attenuated dilatation. Significant relative decreases of 13% of the ejection fraction (EF) and 15% of the fractional shortening (FS) were observed in sham treated animals; respective decreases of 20% and 25% were measured 4 weeks after acellular patch implantation, whereas a steadied function was observed 4 weeks after MSC-patch implantation (relative decreases of 6% for both EF and FS).

Faculty

Faculté des sciences et de médecine

Department

Médecine 3ème année

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