Journal article
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Plasma-functionalized electrospun matrix for biograft development and cardiac function stabilization
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Guex, Anne Géraldine
Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, Switzerland - Department of Cardiovascular Surgery, University Hospital and University of Bern, Switzerland - Graduate School for Cellular and Biomedical Sciences, University of Bern, Switzerland
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Frobert, A.
Cardiology, Department of Medicine, University of Fribourg, Switzerland
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Valentin, Jeremy
Cardiology, Department of Medicine, University of Fribourg, Switzerland
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Fortunato, G.
Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, Switzerland
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Hegemann, D.
Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, Switzerland
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Cook, Stéphane
Cardiology, Department of Medicine, University of Fribourg, Switzerland
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Carrel, Thierry P.
Department of Cardiovascular Surgery, University Hospital and University of Bern, Switzerland
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Tevaearai, H.T.
Department of Cardiovascular Surgery, University Hospital and University of Bern, Switzerland
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Giraud, Marie-Noëlle
Cardiology, Department of Medicine, University of Fribourg, Switzerland
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Published in:
- Acta Biomaterialia. - 2014, vol. 10, no. 7, p. 2996–3006
English
Cardiac tissue engineering approaches can deliver large numbers of cells to the damaged myocardium and have thus increasingly been considered as a possible curative treatment to counteract the high prevalence of progressive heart failure after myocardial infarction (MI). Optimal scaffold architecture and mechanical and chemical properties, as well as immune- and bio-compatibility, need to be addressed. We demonstrated that radio-frequency plasma surface functionalized electrospun poly(ɛ-caprolactone) (PCL) fibres provide a suitable matrix for bone-marrow-derived mesenchymal stem cell (MSC) cardiac implantation. Using a rat model of chronic MI, we showed that MSC-seeded plasma-coated PCL grafts stabilized cardiac function and attenuated dilatation. Significant relative decreases of 13% of the ejection fraction (EF) and 15% of the fractional shortening (FS) were observed in sham treated animals; respective decreases of 20% and 25% were measured 4 weeks after acellular patch implantation, whereas a steadied function was observed 4 weeks after MSC-patch implantation (relative decreases of 6% for both EF and FS).
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Faculty
- Faculté des sciences et de médecine
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Department
- Médecine 3ème année
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Language
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Classification
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Medicine
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License
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License undefined
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/303542
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