Journal article

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Plasma-functionalized electrospun matrix for biograft development and cardiac function stabilization

  • Guex, Anne Géraldine Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, Switzerland - Department of Cardiovascular Surgery, University Hospital and University of Bern, Switzerland - Graduate School for Cellular and Biomedical Sciences, University of Bern, Switzerland
  • Frobert, A. Cardiology, Department of Medicine, University of Fribourg, Switzerland
  • Valentin, Jeremy Cardiology, Department of Medicine, University of Fribourg, Switzerland
  • Fortunato, G. Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, Switzerland
  • Hegemann, D. Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, Switzerland
  • Cook, Stéphane Cardiology, Department of Medicine, University of Fribourg, Switzerland
  • Carrel, Thierry P. Department of Cardiovascular Surgery, University Hospital and University of Bern, Switzerland
  • Tevaearai, H.T. Department of Cardiovascular Surgery, University Hospital and University of Bern, Switzerland
  • Giraud, Marie-Noëlle Cardiology, Department of Medicine, University of Fribourg, Switzerland
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    14.02.2014
Published in:
  • Acta Biomaterialia. - 2014, vol. 10, no. 7, p. 2996–3006
English Cardiac tissue engineering approaches can deliver large numbers of cells to the damaged myocardium and have thus increasingly been considered as a possible curative treatment to counteract the high prevalence of progressive heart failure after myocardial infarction (MI). Optimal scaffold architecture and mechanical and chemical properties, as well as immune- and bio-compatibility, need to be addressed. We demonstrated that radio-frequency plasma surface functionalized electrospun poly(ɛ-caprolactone) (PCL) fibres provide a suitable matrix for bone-marrow-derived mesenchymal stem cell (MSC) cardiac implantation. Using a rat model of chronic MI, we showed that MSC-seeded plasma-coated PCL grafts stabilized cardiac function and attenuated dilatation. Significant relative decreases of 13% of the ejection fraction (EF) and 15% of the fractional shortening (FS) were observed in sham treated animals; respective decreases of 20% and 25% were measured 4 weeks after acellular patch implantation, whereas a steadied function was observed 4 weeks after MSC-patch implantation (relative decreases of 6% for both EF and FS).
Faculty
Faculté des sciences et de médecine
Department
Médecine 3ème année
Language
  • English
Classification
Medicine
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/303542
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