Rapid detection of carbapenemase-producing Enterobacteriaceae from blood cultures

Dortet, Laurent; Bréchard, Ludivine; Poirel, Laurent; Nordmann, Patrice

doi:10.1111/1469-0691.12318

Back

Journal article

+ 1 other files

Rapid detection of carbapenemase-producing Enterobacteriaceae from blood cultures

Dortet, Laurent Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris Sud, France
Bréchard, Ludivine Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris Sud, France
Poirel, Laurent Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris Sud, France - Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Switzerland
Nordmann, Patrice Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris Sud, France - Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Switzerland

2013

Published in:

Clinical Microbiology and Infection. - 2014, vol. 20, no. 4, p. 340-344

English The biochemical-based Carba NP test has been evaluated to detect carbapenemase- producing Enterobacteriaceae (n = 193) directly from spiked blood cultures. It was able to rapidly detect KPC (n = 50), IMP (n = 27), VIM (n = 37), NDM (n = 33) and OXA-48-like producers (n = 46) with sensitivity and specificity of 97.9% and 100%, respectively. This cost-effective technique may be implemented in any microbiology laboratory and offers a reliable test for an early identification of carbapenemase- producing Enterobacteriaceae directly from blood culture that could be useful for the management of infected patients.

Faculty

Faculté des sciences et de médecine

Department

Médecine 3ème année

Language