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Parvalbumin: calcium and magnesium buffering in the distal nephron

  • Olinger, Eric Division of Nephrology and Laboratory of Cell Physiology, UCL Medical School, Brussels, Belgium
  • Schwaller, Beat Unit of Anatomy, Department of Medicine, University of Fribourg, Fribourg, Switzerland
  • Loffing, Johannes Institutes of Physiology and Anatomy, Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
  • Gailly, Philippe Institutes of Physiology and Anatomy, Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
  • Devuyst, Olivier Institutes of Physiology and Anatomy, Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
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    26.08.2012
Published in:
  • Nephrology Dialysis Transplantation. - 2012, vol. 27, no. 11, p. 3988-3994
DCT
Gitelman syndrome
NCC
purinergic signalling
English Parvalbumin (PV) is a classical member of the EF-hand protein superfamily that has been described as a Ca²⁺ buffer and Ca²⁺ transporter/shuttle protein and may also play an additional role in Mg²⁺ handling. PV is exclusively expressed in the early part of the distal convoluted tubule in the human and mouse kidneys. Recent studies in Pvalb knockout mice revealed a role of PV in the distal handling of electrolytes: the lack of PV was associated with a mild salt-losing phenotype with secondary aldosteronism, salt craving and stronger bones compared with controls. A link between the Ca²⁺-buffering capacity of PV and the expression of the thiazide- sensitive Na⁺–Cl⁻ cotransporter was established, which could be relevant to the regulation of sodium transport in the distal nephron. Variants in the PVALB gene that encodes PV have been described, but their relevance to kidney function has not been established. PV is also considered a reliable marker of chromophobe carcinoma and oncocytoma, two neoplasms deriving from the distal nephron. The putative role of PV in tumour genesis remains to be investigated.
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Biological sciences
License
License undefined
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https://folia.unifr.ch/unifr/documents/302649
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