Journal article

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The evolutionary conserved BER1 gene is involved in microtubule stability in yeast

  • Fiechter, Vincent Center for Integrative Genomics, University of Lausanne, Switzerland
  • Cameroni, Elisabetta Division of Biochemistry, Department of Medicine, University of Fribourg, Switzerland
  • Cerutti, Lorenzo Ludwig Institute for Cancer Research, Lausanne, Switzerland
  • De Virgilio, Claudio Division of Biochemistry, Department of Medicine, University of Fribourg, Switzerland
  • Barral, Yves Institute of Biochemistry, Biology Department, ETH Zurich, Switzerland
  • Fankhauser, Christian Center for Integrative Genomics, University of Lausanne, Switzerland
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    07.12.2007
Published in:
  • Current Genetics. - 2008, vol. 53, no. 2, p. 107-115
English In yeast, microtubules are dynamic filaments necessary for spindle and nucleus positioning, as well as for proper chromosome segregation. We identify a function for the yeast gene BER1 (Benomyl REsistant 1) in microtubule stability. BER1 belongs to an evolutionary conserved gene family whose founding member Sensitivity to Red light Reduced is involved in red-light perception and circadian rhythms in Arabidopsis. Here, we present data showing that the ber1Δ mutant is affected in microtubule stability, particularly in presence of microtubule-depolymerising drugs. The pattern of synthetic lethal interactions obtained with the ber1Δ mutant suggests that Ber1 may function in N-terminal protein acetylation. Our work thus suggests that microtubule stability might be regulated through this post-translational modification on yet-to-be determined proteins.
Faculty
Faculté des sciences et de médecine
Department
Département de Biologie
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/300697
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