Journal article
+ 1 other files
The evolutionary conserved BER1 gene is involved in microtubule stability in yeast
-
Fiechter, Vincent
Center for Integrative Genomics, University of Lausanne, Switzerland
-
Cameroni, Elisabetta
Division of Biochemistry, Department of Medicine, University of Fribourg, Switzerland
-
Cerutti, Lorenzo
Ludwig Institute for Cancer Research, Lausanne, Switzerland
-
De Virgilio, Claudio
Division of Biochemistry, Department of Medicine, University of Fribourg, Switzerland
-
Barral, Yves
Institute of Biochemistry, Biology Department, ETH Zurich, Switzerland
-
Fankhauser, Christian
Center for Integrative Genomics, University of Lausanne, Switzerland
Show more…
Published in:
- Current Genetics. - 2008, vol. 53, no. 2, p. 107-115
English
In yeast, microtubules are dynamic filaments necessary for spindle and nucleus positioning, as well as for proper chromosome segregation. We identify a function for the yeast gene BER1 (Benomyl REsistant 1) in microtubule stability. BER1 belongs to an evolutionary conserved gene family whose founding member Sensitivity to Red light Reduced is involved in red-light perception and circadian rhythms in Arabidopsis. Here, we present data showing that the ber1Δ mutant is affected in microtubule stability, particularly in presence of microtubule-depolymerising drugs. The pattern of synthetic lethal interactions obtained with the ber1Δ mutant suggests that Ber1 may function in N-terminal protein acetylation. Our work thus suggests that microtubule stability might be regulated through this post-translational modification on yet-to-be determined proteins.
-
Faculty
- Faculté des sciences et de médecine
-
Department
- Département de Biologie
-
Language
-
-
Classification
-
Biological sciences
-
License
-
License undefined
-
Identifiers
-
-
Persistent URL
-
https://folia.unifr.ch/unifr/documents/300697
Other files
Statistics
Document views: 76
File downloads:
- devirgillio_ecb.pdf: 96
- devirgillio_ecb_sm.pdf: 75