Living with Lethal PIP3 Levels: Viability of Flies Lacking PTEN Restored by a PH Domain Mutation in Akt/PKB
- Stocker, Hugo Zoologisches Institut der Universität Zürich, Switzerland
- Andjelkovic, Mirjana Friedrich Miescher Institute, Basel, Switzerland - Department of Vascular and Metabolic Diseases, F. Hoffmann-La Roche AG, Basel, Switzerland.
- Oldham, Sean Zoologisches Institut der Universität Zürich, Switzerland
- Laffargue, Muriel Medicine Department, Fribourg University, Switzerland
- Wymann, Matthias P. Medicine Department, Fribourg University, Switzerland
- Hemmings, Brian A. Friedrich Miescher Institute, Basel, Switzerland
- Hafen, Ernst Zoologisches Institut der Universität Zürich, Switzerland
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2002
Published in:
- Science. - 2002, vol. 15, no. 5562, p. 2088 - 2091
English
The phosphoinositide phosphatase PTEN is mutated in many human cancers. Although the role of PTEN has been studied extensively, the relative contributions of its numerous potential downstream effectors to deregulated growth and tumorigenesis remain uncertain. We provide genetic evidence in <i>Drosophila melanogaster</i> for the paramount importance of the protein kinase Akt [also called... Show more…
- Faculty
- Faculté des sciences
- Department
- Médecine
- Language
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- English
- Classification
- Biology
- License
- License undefined
- Identifiers
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- RERO DOC 6024
- DOI 10.1126/science.1068094
- Persistent URL
- https://folia.unifr.ch/unifr/documents/300298