Journal article

Statins prevent pulsatile stretch-induced proliferation of human saphenous vein smooth muscle cells via inhibition of Rho/Rho-kinase pathway

  • Kozai, Toshiyuki Cardiovascular Research, Institute of Physiology, University of Zürich, Switzerland - Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
  • Eto, Masato Cardiovascular Research, Institute of Physiology, University of Zürich, Switzerland
  • Yang, Zhihong Cardiology, Cardiovascular Center, University Hospital, Zürich, Switzerland - Cardiovascular Research, Institute of Physiology, University of Zürich, Switzerland - Vascular Biology, Institute of Physiology, University of Fribourg, Switzerland
  • Shimokawa, Hiroaki Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
  • Lüscher, Thomas F. Cardiology, Cardiovascular Center, University Hospital, Zürich, Switzerland - Cardiovascular Research, Institute of Physiology, University of Zürich, Switzerland
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    11.08.2005
Published in:
  • Cardiovascular Research. - 2005, vol. 68, no. 3, p. 475-482
English <p>Objective:</p> Pulsatile forces regulate vascular remodeling and trigger vascular diseases such as saphenous vein graft disease. The saphenous vein is exposed to high pressure and pulsatility only after implantation. Statins have been proved to reduce the incidence of vein graft failure. Thus, we investigated the molecular mechanisms of pulsatile stretch-induced saphenous vein smooth... Show more…
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/300066