Influence of TOR kinase on lifespan in C. elegans
- Vellai, Tibor Department of Biology, University of Fribourg, Switzerland
- Takacs-Vellai, Krisztina Department of Biology, University of Fribourg, Switzerland
- Zhang, Yue Department of Biology, University of Fribourg, Switzerland
- Kovacs, Attila L. Department of General Zoology, Eötvös Loránd University, Budapest, Hungary
- Orosz, László Department of Genetics, Eötvös Loránd University, Budapest, Hungary - Agricultural Biotechnology Centre, Gödöllö, Hungary
- Müller, Fritz Department of Biology, University of Fribourg, Switzerland
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11.12.2003
Published in:
- Nature. - 2003, vol. 426, p. 620
English
The group of enzymes known as TOR (for 'target of rapamycin') kinases regulates cell growth and proliferation in response to nutrients and hormone-dependent mitogenic signals<sup>1, 2</sup>. Here we show that TOR deficiency in the nematode <i>Caenorhabditis elegans</i> more than doubles its natural lifespan. This new function for TOR signalling in ageing control may represent a link between... Show more…
- Faculty
- Faculté des sciences
- Department
- Biologie
- Language
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- English
- Classification
- Biology
- License
- License undefined
- Identifiers
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- RERO DOC 5997
- DOI 10.1038/426620a
- Persistent URL
- https://folia.unifr.ch/unifr/documents/300051