Influence of TOR kinase on lifespan in C. elegans
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Vellai, Tibor
Department of Biology, University of Fribourg, Switzerland
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Takacs-Vellai, Krisztina
Department of Biology, University of Fribourg, Switzerland
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Zhang, Yue
Department of Biology, University of Fribourg, Switzerland
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Kovacs, Attila L.
Department of General Zoology, Eötvös Loránd University, Budapest, Hungary
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Orosz, László
Department of Genetics, Eötvös Loránd University, Budapest, Hungary - Agricultural Biotechnology Centre, Gödöllö, Hungary
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Müller, Fritz
Department of Biology, University of Fribourg, Switzerland
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Published in:
- Nature. - 2003, vol. 426, p. 620
English
The group of enzymes known as TOR (for 'target of rapamycin') kinases regulates cell growth and proliferation in response to nutrients and hormone-dependent mitogenic signals<sup>1, 2</sup>. Here we show that TOR deficiency in the nematode <i>Caenorhabditis elegans</i> more than doubles its natural lifespan. This new function for TOR signalling in ageing control may represent a link between... Show more…
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Faculty
- Faculté des sciences
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Department
- Biologie
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Language
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Classification
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Biology
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License
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License undefined
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/300051