Journal article

Influence of TOR kinase on lifespan in C. elegans

  • Vellai, Tibor Department of Biology, University of Fribourg, Switzerland
  • Takacs-Vellai, Krisztina Department of Biology, University of Fribourg, Switzerland
  • Zhang, Yue Department of Biology, University of Fribourg, Switzerland
  • Kovacs, Attila L. Department of General Zoology, Eötvös Loránd University, Budapest, Hungary
  • Orosz, László Department of Genetics, Eötvös Loránd University, Budapest, Hungary - Agricultural Biotechnology Centre, Gödöllö, Hungary
  • Müller, Fritz Department of Biology, University of Fribourg, Switzerland
Show more…
    11.12.2003
Published in:
  • Nature. - 2003, vol. 426, p. 620
English The group of enzymes known as TOR (for 'target of rapamycin') kinases regulates cell growth and proliferation in response to nutrients and hormone-dependent mitogenic signals1, 2. Here we show that TOR deficiency in the nematode Caenorhabditis elegans more than doubles its natural lifespan. This new function for TOR signalling in ageing control may represent a link between nutrition, metabolism and longevity.
Faculty
Faculté des sciences et de médecine
Department
Département de Biologie
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/300051
Statistics

Document views: 8 File downloads:
  • muller_itk.pdf: 2