Influence of TOR kinase on lifespan in C. elegans
- Vellai, Tibor Department of Biology, University of Fribourg, Switzerland
- Takacs-Vellai, Krisztina Department of Biology, University of Fribourg, Switzerland
- Zhang, Yue Department of Biology, University of Fribourg, Switzerland
- Kovacs, Attila L. Department of General Zoology, Eötvös Loránd University, Budapest, Hungary
- Orosz, László Department of Genetics, Eötvös Loránd University, Budapest, Hungary - Agricultural Biotechnology Centre, Gödöllö, Hungary
- Müller, Fritz Department of Biology, University of Fribourg, Switzerland
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11.12.2003
Published in:
- Nature. - 2003, vol. 426, p. 620
English
The group of enzymes known as TOR (for 'target of rapamycin') kinases regulates cell growth and proliferation in response to nutrients and hormone-dependent mitogenic signals1, 2. Here we show that TOR deficiency in the nematode Caenorhabditis elegans more than doubles its natural lifespan. This new function for TOR signalling in ageing control may represent a link between nutrition, metabolism and longevity.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Biologie
- Language
-
- English
- Classification
- Biology
- License
- License undefined
- Identifiers
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- RERO DOC 5997
- DOI 10.1038/426620a
- Persistent URL
- https://folia.unifr.ch/unifr/documents/300051
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