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Journal article

Circadian rhythms in murine pups develop in absence of a functional maternal circadian clock

  • Jud, Corinne Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland
  • Albrecht, Urs Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland
    2006
Published in:
  • Journal of Biological Rhythms. - 2006, vol. 21, no. 2, p. 149-154
circadian rhythm
development
synchronization
Per1
Per2
Cry1
English A genetic approach was used to investigate whether the emergence of circadian rhythms in murine pups is dependent on a functional maternal clock. Arrhythmic females bearing either the mPer1Brdm1/Per2Brdm1 or mPer2Brdm1/Cry1-/- double-mutant genotype were crossed with wild-type males under constant darkness. The heterozygous offspring have the genetic constitution for a functional circadian clock. Individual pups born to arrhythmic mPer1Brdm1/Per2Brdm1 and mPer2Brdm1/Cry1-/- mothers in constant darkness without external zeitgeber developed normal circadian rhythms, but their clocks were less synchronized to each other compared to wild-type animals. These findings indicate that development of circadian rhythms does not depend on a functional circadian clock in maternal tissue, extending previous findings obtained from pups born to SCN-lesioned mothers.
Faculty
Faculté des sciences et de médecine
Department
Département de Biologie
Language
  • English
Classification
Medicine
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/299909
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