Jud, Corinne Albrecht, Urs 2006 A genetic approach was used to investigate whether the emergence of circadian rhythms in murine pups is dependent on a functional maternal clock. Arrhythmic females bearing either the mPer1^Brdm1/Per2^Brdm1 or mPer2^Brdm1/Cry1^-/- double-mutant genotype were crossed with wild-type males under constant darkness. The heterozygous offspring have the genetic constitution for a functional circadian clock. Individual pups born to arrhythmic mPer1^Brdm1/Per2^Brdm1 and mPer2^Brdm1/Cry1^-/- mothers in constant darkness without external zeitgeber developed normal circadian rhythms, but their clocks were less synchronized to each other compared to wild-type animals. These findings indicate that development of circadian rhythms does not depend on a functional circadian clock in maternal tissue, extending previous findings obtained from pups born to SCN-lesioned mothers. application/pdf https://folia.unifr.ch/global/documents/299909 https://folia.unifr.ch/documents/299909/files/albrecht_crm.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.1177/0748730406286264 info:eu-repo/semantics/openAccess License undefined Journal of Biological Rhythms. - 2006, vol. 21, no. 2, p. 149-154 circadian rhythm development synchronization Per1 Per2 Cry1 info:eu-repo/classification/udc/61 Circadian rhythms in murine pups develop in absence of a functional maternal circadian clock http://purl.org/coar/resource_type/c_6501