The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation
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Solinas, Giovanni
Department of Medicine, Division of Physiology, University of Fribourg, Switzerland - Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland
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Summermatter, Serge
Department of Medicine, Division of Physiology, University of Fribourg, Switzerland
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Mainieri, Davide
Department of Medicine, Division of Physiology, University of Fribourg, Switzerland
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Gubler, Marcel
Department of Vascular and Metabolic Diseases, Hoffmann-La Roche, Switzerland
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Pirola, Luciano
Faculty of Medicine, INSERM, Nice, France
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Wymann, Matthias P.
Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland
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Rusconi, Sandro
Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland
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Montani, Jean-Pierre
Department of Medicine, Division of Physiology, University of Fribourg, Switzerland
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Seydoux, Josiane
Department of Physiology, Faculty of Medicine, University of Geneva, Switzerland
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Published in:
- FEBS Letters. - 2004, vol. 577, no. 3, p. 539-544
English
We report here studies that integrate data of respiration rate from mouse skeletal muscle in response to leptin and pharmacological interference with intermediary metabolism, together with assays for phosphatidylinositol 3-kinase (PI3K) and AMP- activated protein kinase (AMPK). Our results suggest that the direct effect of leptin in stimulating thermogenesis in skeletal muscle is mediated by substrate cycling between de novo lipogenesis and lipid oxidation, and that this cycle requires both PI3K and AMPK signaling. This substrate cycling linking glucose and lipid metabolism to thermogenesis provides a novel thermogenic mechanism by which leptin protects skeletal muscle from excessive fat storage and lipotoxicity.
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Faculty
- Faculté des sciences et de médecine
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Department
- Département de Médecine
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Language
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Classification
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Medicine
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License
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License undefined
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/299659
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