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Journal article

The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation

  • Solinas, Giovanni Department of Medicine, Division of Physiology, University of Fribourg, Switzerland - Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland
  • Summermatter, Serge Department of Medicine, Division of Physiology, University of Fribourg, Switzerland
  • Mainieri, Davide Department of Medicine, Division of Physiology, University of Fribourg, Switzerland
  • Gubler, Marcel Department of Vascular and Metabolic Diseases, Hoffmann-La Roche, Switzerland
  • Pirola, Luciano Faculty of Medicine, INSERM, Nice, France
  • Wymann, Matthias P. Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland
  • Rusconi, Sandro Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland
  • Montani, Jean-Pierre Department of Medicine, Division of Physiology, University of Fribourg, Switzerland
  • Seydoux, Josiane Department of Physiology, Faculty of Medicine, University of Geneva, Switzerland
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    11.11.2004
Published in:
  • FEBS Letters. - 2004, vol. 577, no. 3, p. 539-544
Obesity
Diabetes
Lipotoxicity
Gluco-lipotoxicity
Insulin resistance
Phosphatidylinositol 3-kinase
AMP-activated protein kinase
Sterol regulatory element binding protein-1c
English We report here studies that integrate data of respiration rate from mouse skeletal muscle in response to leptin and pharmacological interference with intermediary metabolism, together with assays for phosphatidylinositol 3-kinase (PI3K) and AMP- activated protein kinase (AMPK). Our results suggest that the direct effect of leptin in stimulating thermogenesis in skeletal muscle is mediated by substrate cycling between de novo lipogenesis and lipid oxidation, and that this cycle requires both PI3K and AMPK signaling. This substrate cycling linking glucose and lipid metabolism to thermogenesis provides a novel thermogenic mechanism by which leptin protects skeletal muscle from excessive fat storage and lipotoxicity.
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Medicine
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/299659
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