The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation

Solinas, Giovanni; Summermatter, Serge; Mainieri, Davide; Gubler, Marcel; Pirola, Luciano; Wymann, Matthias P.; Rusconi, Sandro; Montani, Jean-Pierre; Seydoux, Josiane

doi:10.1016/j.febslet.2004.10.066

Back

Journal article

The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation

Solinas, Giovanni Department of Medicine, Division of Physiology, University of Fribourg, Switzerland - Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland
Summermatter, Serge Department of Medicine, Division of Physiology, University of Fribourg, Switzerland
Mainieri, Davide Department of Medicine, Division of Physiology, University of Fribourg, Switzerland
Gubler, Marcel Department of Vascular and Metabolic Diseases, Hoffmann-La Roche, Switzerland
Pirola, Luciano Faculty of Medicine, INSERM, Nice, France
Wymann, Matthias P. Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland
Rusconi, Sandro Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland
Montani, Jean-Pierre Department of Medicine, Division of Physiology, University of Fribourg, Switzerland
Seydoux, Josiane Department of Physiology, Faculty of Medicine, University of Geneva, Switzerland

11.11.2004

Published in:

FEBS Letters. - 2004, vol. 577, no. 3, p. 539-544

Sterol regulatory element binding protein-1c

English We report here studies that integrate data of respiration rate from mouse skeletal muscle in response to leptin and pharmacological interference with intermediary metabolism, together with assays for phosphatidylinositol 3-kinase (PI3K) and AMP- activated protein kinase (AMPK). Our results suggest that the direct effect of leptin in stimulating thermogenesis in skeletal muscle is mediated by substrate cycling between de novo lipogenesis and lipid oxidation, and that this cycle requires both PI3K and AMPK signaling. This substrate cycling linking glucose and lipid metabolism to thermogenesis provides a novel thermogenic mechanism by which leptin protects skeletal muscle from excessive fat storage and lipotoxicity.

Faculty

Faculté des sciences et de médecine

Department

Département de Médecine

Language