Thrombin Stimulates Human Endothelial Arginase Enzymatic Activity via RhoA/ROCK Pathway
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Ming, Xiu-Fen
Department of Medicine, Division of Physiology University of Fribourg, Switzerland
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Barandier, Christine
Department of Medicine, Division of Physiology University of Fribourg, Switzerland
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Viswambharan, Hema
Department of Medicine, Division of Physiology University of Fribourg, Switzerland
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Kwak, Brenda R.
Division of Cardiology, University Hospital Geneva
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Mach, François
Division of Cardiology, University Hospital Geneva
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Mazzolai, Lucia
Division of Hypertension and Vascular Medicine, University Hospital, Lausanne, Switzerland
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Hayoz, Daniel
Division of Hypertension and Vascular Medicine, University Hospital, Lausanne, Switzerland
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Ruffieux, Jean
Department of Medicine, Division of Physiology University of Fribourg, Switzerland
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Rusconi, Sandro
Department of Medicine, Division of Biochemistry University of Fribourg, Switzerland
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Montani, Jean-Pierre
Department of Medicine, Division of Physiology University of Fribourg, Switzerland
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Yang, Zhihong
Department of Medicine, Division of Physiology University of Fribourg, Switzerland
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Published in:
- Circulation. - 2004, vol. 110, no. 3708-3714
English
Background— Arginase competes with endothelial nitric oxide synthase (eNOS) for the substrate L-arginine and decreases NO production. This study investigated regulatory mechanisms of arginase activity in endothelial cells and its role in atherosclerosis. Methods and Results— In human endothelial cells isolated from umbilical veins, thrombin concentration- and time-dependently stimulated... Show more…
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Faculty
- Faculté des sciences
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Department
- Médecine
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Language
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Classification
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Medicine
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License
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License undefined
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/299618