Thrombin Stimulates Human Endothelial Arginase Enzymatic Activity via RhoA/ROCK Pathway
- Ming, Xiu-Fen Department of Medicine, Division of Physiology University of Fribourg, Switzerland
- Barandier, Christine Department of Medicine, Division of Physiology University of Fribourg, Switzerland
- Viswambharan, Hema Department of Medicine, Division of Physiology University of Fribourg, Switzerland
- Kwak, Brenda R. Division of Cardiology, University Hospital Geneva
- Mach, François Division of Cardiology, University Hospital Geneva
- Mazzolai, Lucia Division of Hypertension and Vascular Medicine, University Hospital, Lausanne, Switzerland
- Hayoz, Daniel Division of Hypertension and Vascular Medicine, University Hospital, Lausanne, Switzerland
- Ruffieux, Jean Department of Medicine, Division of Physiology University of Fribourg, Switzerland
- Rusconi, Sandro Department of Medicine, Division of Biochemistry University of Fribourg, Switzerland
- Montani, Jean-Pierre Department of Medicine, Division of Physiology University of Fribourg, Switzerland
- Yang, Zhihong Department of Medicine, Division of Physiology University of Fribourg, Switzerland
-
29.11.2004
Published in:
- Circulation. - 2004, vol. 110, no. 3708-3714
English
Background— Arginase competes with endothelial nitric oxide synthase (eNOS) for the substrate L-arginine and decreases NO production. This study investigated regulatory mechanisms of arginase activity in endothelial cells and its role in atherosclerosis. Methods and Results— In human endothelial cells isolated from umbilical veins, thrombin concentration- and time-dependently stimulated... Show more…
- Faculty
- Faculté des sciences
- Department
- Médecine
- Language
-
- English
- Classification
- Medicine
- License
- License undefined
- Identifiers
-
- RERO DOC 4366
- DOI 10.1161/01.CIR.0000142867.26182.32
- Persistent URL
- https://folia.unifr.ch/unifr/documents/299618