Over-expression of parvalbumin in transgenic mice rescues motoneurons from injury-induced cell death
- Dekkers, J. Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London UK
- Bayley, P. Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London UK
- Dick, J. R. T. Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London UK
- Schwaller, Beat Institute of Histology, Department of Medicine, University of Fribourg, Switzerland
- Berchtold, M. W. Department of Molecular Cell Biology, Institute of Molecular Biology, University of Copenhagen, Denmark
- Greensmith, L. Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London UK
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23.12.2004
Published in:
- Neuroscience. - 2004, vol. 123(2), no. 459-466
English
Following nerve injury in neonatal rats, a large proportion of motoneurons die, possibly as a consequence of an increase in vulnerability to the excitotoxic effects of glutamate. Calcium-dependent glutamate excitotoxicity is thought to play a significant role not only in injury-induced motoneuron death, but also in motoneuron degeneration in diseases such as amyotrophic lateral sclerosis... Show more…
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Médecine
- Language
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- English
- Classification
- Biology
- License
- License undefined
- Identifiers
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- RERO DOC 4886
- DOI 10.1016/j.neuroscience.2003.07.013
- Persistent URL
- https://folia.unifr.ch/unifr/documents/299544