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Journal article

Derepressed transfer properties leading to the efficient spread of the plasmid encoding carbapenemase OXA-48

Université de Fribourg

  • Potron, Anaïs INSERM U914, Emerging Resistance to Antibiotics, Faculté de Médecine et Université Paris-Sud, K. Bicêtre, France
  • Poirel, Laurent INSERM U914, Emerging Resistance to Antibiotics, Faculté de Médecine et Université Paris-Sud, K. Bicêtre, France - Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland
  • Nordmann, Patrice INSERM U914, Emerging Resistance to Antibiotics, Faculté de Médecine et Université Paris-Sud, K. Bicêtre, France - Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland
    01.01.2014
Published in:
  • Antimicrobial Agents and Chemotherapy, 2013, vol. 58, no. 1, p. 467–471
English The current emergence of the carbapenemase OXA-48 among Enterobacteriaceae is related to the spread of a single IncL/M-type plasmid, pOXA-48a. This plasmid harbors the <em>bla</em><sub>OXA-48</sub> gene within a composite transposon, Tn<em>1999</em>, which is inserted into the <em>tir</em> gene, encoding a transfer inhibition protein. We showed that the insertion of Tn<em>1999</em> into the... Show more…
Language
  • English
Identifiers
Classification
Medicine
Faculty
Faculté des sciences
Department
Médecine
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Persistent URL
https://folia.unifr.ch/global/documents/303473