Back
balogetal.currentopinioninbiotechnology2024-aam
Journal article

Does the surface charge of the nanoparticles drive nanoparticle–cell membrane interactions?

DOKPE

Show more…
  • 2024
Published in:
  • Current Opinion in Biotechnology. - Elsevier BV. - 2024, vol. 87, p. 103128
Nanoparticles
surface charge
protein corona
cell membrane interactions
English Classical Coulombic interaction, characterized by electrostatic interactions mediated through surface charges, is often regarded as the primary determinant in nanoparticles' cellular association and internalization. However, the intricate physicochemical properties of particle surfaces, biomolecular coronas, and cell surfaces defy this oversimplified perspective. Moreover, the nanometrological techniques employed to characterize nanoparticles in complex physiological fluids often exhibit limited accuracy and reproducibility. A more comprehensive understanding of nanoparticle-cell membrane interactions, extending beyond attractive forces between oppositely charged surfaces, necessitates the establishment of databases through rigorous physical, chemical,
and biological characterization supported by nanoscale analytics. Additionally, computational approaches, such as in silico modeling and machine learning, play a crucial role in unraveling the complexities of these interactions.
Faculty
Faculté des sciences et de médecine
Department
Adolphe Merkle Institute
Language
  • English
Classification
Engineering materials
License
CC BY
Open access status
green
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/332921
Statistics
Document views: 7 File downloads:
  • balogetal.currentopinioninbiotechnology2024-aam.pdf: 8