Occurrence and spread of carbapenemase‐producing Enterobacterales (CPE) in the food chain in the EU/EFTA. Part 1: 2025 update
DOKPE
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EFSA BIOHAZ Panel (EFSA Panel on Biological Hazards)
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Allende, Ana
ORCID
Spanish National Research Council (CSIC)
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Álvarez‐Ordóñez, Avelino
University of León, Spain
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Bortolaia, Valeria
ORCID
Statens Serum Institut, Copenhagen, Denmark
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Bover‐Cid, Sara
IRTA Institute of Agrifood Research and Technology, Caldes de Montbui, Spain
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De Cesare, Alessandra
University of Bologna, Italy
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Dohmen, Wietske
Utrecht University, Netherland
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Guillier, Laurent
ORCID
Anses: Maisons-Alfort, Île-de-France, France
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Herman, Lieve
Flanders Research Institute for Agriculture, Fisheries and Food, Merelbeke-Melle, Belgium
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Jacxsens, Liesbeth
Ghent University, Ghent, Belgium
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Mughini‐Gras, Lapo
University of Utrecht
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Nauta, Maarten
ORCID
Statens Serum Institut, Copenhagen, Denmark
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Ottoson, Jakob
ORCID
National Food Administration, Uppsala, Sweden
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Pérez‐Rodríguez, Fernando
University of Cordoba, Spain
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Skandamis, Panagiotis
ORCID
Agricultural University of Athens, Greece
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Suffredini, Elisabetta
ORCID
Istituto Superiore di Sanità, Roma, Italy
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Argüello, Hector
ORCID
Universidad de León, Spain
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Bengtsson‐Palme, Johan
ORCID
University of Gothenburg, Sweden
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Carattoli, Alessandra
ORCID
Sapienza University of Rome, Italy
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Kohlenberg, Anke
ORCID
European Centre for Disease Prevention and Control, Stockholm, Sweden
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Monnet, Dominique L.
ORCID
European Centre for Disease Prevention and Control, Stockholm, Sweden
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Poirel, Laurent
ORCID
University of Fribourg
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Guerra, Beatriz
EFSA European Food Safety Authority, Parma, Italy
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García‐Fierro, Raquel
ORCID
Anses: Maisons-Alfort, Île-de-France, France
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Liébana, Ernesto
EFSA European Food Safety Authority, Parma, Italy
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Goudjihounde, Sonagnon Martin
EFSA European Food Safety Authority, Parma, Italy
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Ferrer‐Bustins, Núria
ORCID
EFSA European Food Safety Authority, Parma, Italy
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Rabbås, Hanne
Norwegian University of Life Sciences, Ås, Norway
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Peixe, Luisa
University of Porto
Show more…
Published in:
- EFSA Journal. - Chichester, UK: Wiley. - 2025, vol. 23, no. 4
English
Carbapenemase-producing Enterobacterales (CPE) have been reported in the food chain in 14 out of 30 EU/EFTA countries. Commonly reported genes are blaVIM-1, blaOXA-48 and blaOXA-181, followed by blaNDM-5 and blaIMI-1. Escherichia coli, target of most of the studies, Enterobacter cloacae complex, Klebsiella pneumoniae complex and Salmonella Infantis are the most frequent CPE. E. coli isolates show a high clonal diversity. IncHI2 (blaVIM-1 and blaOXA-162), IncC (blaVIM-1 and blaNDM-1), IncX3 (blaNDM-5 and blaOXA-181), IncI and IncL (blaOXA-48) plasmids are frequently reported. Most reports are from terrestrial food-producing animals and their environments – mainly pigs, followed by bovines and poultry and with occasional reports of meat thereof (targets of the EU monitoring and follow up trace back investigations). Few studies have investigated foods of aquatic animal origin and of non-animal origin, finding a great CPE diversity. A notable increase in the number of CPE detections has been observed, predominantly from pigs, with a surge in certain countries in 2021 (blaOXA-181, Italy) and 2023 (blaOXA-48, Spain; blaOXA-181, blaOXA-48, blaOXA-244 and blaNDM-5, Portugal). Very few data points to circumstantial evidence of CPE transmission, clonal and/or horizontal gene spread within the food chain and from/to humans. Various methods are used in the EU/EFTA countries to detect and characterise CPE in the food chain. Improvement of their sensitivity should be investigated. Ten out of 30 EU/EFTA countries have specific contingency plans for CPE control, being epidemiological investigations (e.g. trace-back) a common action included in those plans. Overall, data remain scarce for the bacterial species and sources beyond those systematically monitored. Recommendations to fill data gaps on other bacterial species and sources, dissemination pathways and optimisation of detection methods are given. A One Health approach to address the drivers of CPE spread in the food chain is needed.
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Faculty
- Faculté des sciences et de médecine
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Department
- Médecine 3ème année
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Language
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Classification
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Biotechnology
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License
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CC BY-ND
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Open access status
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gold
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/332167
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