Journal article

Molecular dynamics simulations of intracellular lipid droplets: a new tool in the toolbox

DOKPE

  • 2024
Published in:
  • FEBS Letters. - Chicherster, UK : Wiley. - 2024, p. 1-11
English Lipid droplets (LDs) are ubiquitous intracellular organelles with a central role in multiple lipid metabolic pathways. However, identifying correlations between their structural properties and their biological activity has proved challenging, owing to their unique physicochemical properties as compared with other cellular membranes. In recent years, molecular dynamics (MD) simulations, a computational methodology allowing the accurate description of molecular assemblies down to their individual components, have been demonstrated to be a useful and powerful approach for studying LD structural and dynamical properties. In this short review, we attempt to highlight, as comprehensively as possible, how MD simulations have contributed to our current understanding of multiple molecular mechanisms involved in LD biology.
Faculty
Faculté des sciences et de médecine
Department
Département de Biologie
Language
  • English
Classification
Biological sciences
License
CC BY-NC
Open access status
hybrid
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/328457
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