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muelleretal.2017
Journal article

Neural response to catecholamine depletion in remitted bulimia nervosa: Relation to depression and relapse

DOKPE

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  • 2017
Published in:
  • European Neuropsychopharmacology. - Amsterdam : Elsevier BV. - 2017, vol. 27, no. 7, p. 633-646
Alpha-methyl-paratyrosine
Arterial spin labeling
Bulimia nervosa
Catecholamine depletion
Cerebral blood flow
Relapse
English Bulimia nervosa has been associated with a dysregulated catecholamine system. Nevertheless, the influence of this dysregulation on bulimic symptoms, on neural activity, and on the course of the illness is not clear yet. An instructive paradigm for directly investigating the relationship between catecholaminergic functioning and bulimia nervosa has involved the behavioral and neural responses to experimental catecholamine depletion. The purpose of this study was to examine the neural substrate of catecholaminergic dysfunction in bulimia nervosa and its relationship to relapse. In a randomized, double-blind and crossover study design, catecholamine depletion was achieved by using the oral administration of alpha-methyl-paratyrosine (AMPT) over 24 h in 18 remitted bulimic (rBN) and 22 healthy (HC) female participants. Cerebral blood flow (CBF) was measured using a pseudo continuous arterial spin labeling (pCASL) sequence. In a follow-up telephone interview, bulimic relapse was assessed. Following AMPT, rBN participants revealed an increased vigor reduction and CBF decreases in the pallidum and posterior midcingulate cortex (pMCC) relative to HC participants showing no CBF changes in these regions. These results indicated that the pallidum and the pMCC are the functional neural correlates of the dysregulated catecholamine system in bulimia nervosa. Bulimic relapse was associated with increased depressive symptoms and CBF reduction in the hippocampus/parahippocampal gyrus following catecholamine depletion. AMPT-induced increased CBF in this region predicted staying in remission. These findings demonstrated the importance of depressive symptoms and the stress system in the course of bulimia nervosa.
Faculty
Faculté des sciences et de médecine
Department
Master en médecine
Language
  • English
Classification
Pathology, clinical medicine
License
CC BY-NC-ND
Open access status
hybrid
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/327685
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