A neuroeconomic investigation of 5-HTT/5-HT1A gene variation, social anxiety, and risk-taking behavior
DOKPE
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Stamatis, Caitlin A.
ORCID
University of Miami, FL, USA
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Engelmann, Jan B.
ORCID
University of Amsterdam, Netherlands
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Ziegler, Christiane
ORCID
University of Freiburg, Germany
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Domschke, Katharina
ORCID
University of Freiburg, Germany
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Hasler, Gregor
ORCID
University of Fribourg, Switzerland
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Timpano, Kiara R.
ORCID
University of Miami, FL, USA
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Published in:
- ANXIETY, STRESS, & COPING. - London : Informa UK Limited. - 2020, vol. 33, no. 2, p. 176-192
English
Background and objectives:
Although approaches combining behavioral genetics and neuroeconomics have advanced models of addiction, no study has synthesized these methods to elucidate mechanisms of competing risk-approachand risk-avoidance in social anxiety (SA). Grounded in dual-mode models of serotonergic systems and self-regulation, this study investigated associations between SA, serotonin transporter 5-HTT (LPR; rs25531) and receptor 5-HT1A genes, and risk-taking on behavioral and self-report measures.
Design and methods:
Young adults (N = 309) completed a neuroeconomic task measuring gambling attractiveness (δ), reward probability discrimination (γ), and risk attitudes (α). Risk genotypes included 5-HTT (LPR; rs25531) low-expression variants (SS/SLG/LGLG), and 5-HT1A (rs6295) GG.
Results:
Path analysis revealed that SA related to increased gambling attractiveness, but only for 5-HT1A risk groups. Although the 5-HTT (LPR; rs25531) risk genotypes and self-reported SA predicted lower social risk-taking, high-SA individuals who exhibited more accurate reward probability discrimination (γ) reported taking increased social risks.
Conclusion:
In line with dual-mode models, results suggest that SA predicts behavioral risk-approach at the basic decision-making level, along with self-reported social risk-avoidance, modulated by serotonergic genotypes. High-SA individuals with more accurate assessments of reward probabilities may engage in greater social risk-taking, perhaps reflecting an adaptive tendency to approach feared situations.
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Faculty
- Faculté des sciences et de médecine
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Department
- Master en médecine
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Language
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Classification
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Medicine
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License
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License undefined
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Open access status
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green
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/327492
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