Associations between heart rate variability, peripheral inflammatory markers and major depressive disorder
DOKPE
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Buchmann, Andreas
ORCID
University of Bern, Switzerland
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Ritter, Christopher
ORCID
University of Bern, Switzerland
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Müller, Sabrina Theresia
University of Bern, Switzerland
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Haynes, Melanie
ORCID
University of Bern, Switzerland
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Ghisleni, Carmen
ORCID
University Children's Hospital Zurich, Switzerland
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Tuura, Ruth
ORCID
University Children's Hospital Zurich, Switzerland
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Hasler, Gregor
ORCID
University of Fribourg
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Published in:
- Journal of Affective Disorders. - Elsevier B.V.. - 2022, vol. 304, p. 93-101
English
Background: Measures for the irregularity of the heartbeat, for example respiratory sinus arrhythmia, have been implicated as a measure for restorative functions of the vegetative nervous system. Methods: In the current observational study, we investigated 265 subjects, 70 of whom had a lifetime history of major depression, with a plethysmographic heartbeat monitor, blood sampling, as well as a range of psychiatric questionnaires. Results: Subjects with a history of MDE had significantly reduced respiratory sinus arrhythmia (RSA) as compared to never-depressed controls; in the whole sample, higher RSA went with lower anxiety/fear variables, especially in subscores related to cardiac symptoms as well as being afraid of dying. A reduced RSA was also associated with an increased concentration of cytokines (TNFa, IL1a, IL6, IFNg) and thyroid-stimulating hormone in the serum, pointing to a possible triangular relationship between immune system, vegetative nervous system, and emotional dysregulation. Limitations: We used a plethysmographic device for the measurement of heartbeat instead of an electrocardiogram, and had a single time point only. Conclusions: This data corroborate the idea that a disequilibrium of the vegetative nervous, especially if accompanied by a dysregulation system in immune function, can increase the risk for depression. Conversely, vagal stimulation and anti-inflammatory treatments may support the treatment with antidepressants.
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Faculty
- Faculté des sciences et de médecine
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Department
- Master en médecine
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Language
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Classification
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Pathology, clinical medicine
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License
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CC BY-NC-ND
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Open access status
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gold
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/327401
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