Associations between heart rate variability, peripheral inflammatory markers and major depressive disorder
DOKPE
- Buchmann, Andreas ORCID University of Bern, Switzerland
- Ritter, Christopher ORCID University of Bern, Switzerland
- Müller, Sabrina Theresia University of Bern, Switzerland
- Haynes, Melanie ORCID University of Bern, Switzerland
- Ghisleni, Carmen ORCID University Children's Hospital Zurich, Switzerland
- Tuura, Ruth ORCID University Children's Hospital Zurich, Switzerland
- Hasler, Gregor ORCID University of Fribourg
- 2022
Published in:
- Journal of Affective Disorders. - Elsevier B.V.. - 2022, vol. 304, p. 93-101
English
Background: Measures for the irregularity of the heartbeat, for example respiratory sinus arrhythmia, have been implicated as a measure for restorative functions of the vegetative nervous system. Methods: In the current observational study, we investigated 265 subjects, 70 of whom had a lifetime history of major depression, with a plethysmographic heartbeat monitor, blood sampling, as well as a range of psychiatric questionnaires. Results: Subjects with a history of MDE had significantly reduced respiratory sinus arrhythmia (RSA) as compared to never-depressed controls; in the whole sample, higher RSA went with lower anxiety/fear variables, especially in subscores related to cardiac symptoms as well as being afraid of dying. A reduced RSA was also associated with an increased concentration of cytokines (TNFa, IL1a, IL6, IFNg) and thyroid-stimulating hormone in the serum, pointing to a possible triangular relationship between immune system, vegetative nervous system, and emotional dysregulation. Limitations: We used a plethysmographic device for the measurement of heartbeat instead of an electrocardiogram, and had a single time point only. Conclusions: This data corroborate the idea that a disequilibrium of the vegetative nervous, especially if accompanied by a dysregulation system in immune function, can increase the risk for depression. Conversely, vagal stimulation and anti-inflammatory treatments may support the treatment with antidepressants.
- Faculty
- Faculté des sciences et de médecine
- Department
- Master en médecine
- Language
-
- English
- Classification
- Pathology, clinical medicine
- License
- CC BY-NC-ND
- Open access status
- gold
- Identifiers
-
- DOI 10.1016/j.jad.2022.02.017
- ISSN 0165-0327
- Persistent URL
- https://folia.unifr.ch/unifr/documents/327401
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