Back
journal.pone.0281986
Journal article

EEG Beta functional connectivity decrease in the left amygdala correlates with the affective pain in fibromyalgia: A pilot study

DOKPE

  • Makowka, Soline ORCID Faculty of Science and Medicine, Department of Neuroscience and Movement Science, Laboratory for Neurorehabilitation Science, Medicine Section, University of Fribourg, Fribourg, Switzerland
  • Mory, Lliure-Naima ORCID Faculty of Science and Medicine, Department of Neuroscience and Movement Science, Laboratory for Neurorehabilitation Science, Medicine Section, University of Fribourg, Fribourg, Switzerland, Neurorehabilitation Division, Fribourg Hospital Meyriez/Murten, Fribourg, Switzerland
  • Mouthon, Michaël ORCID Faculty of Science and Medicine, Department of Neuroscience and Movement Science, Laboratory for Neurorehabilitation Science, Medicine Section, University of Fribourg, Fribourg, Switzerland
  • Mancini, Christian Faculty of Science and Medicine, Department of Neuroscience and Movement Science, Laboratory for Neurorehabilitation Science, Medicine Section, University of Fribourg, Fribourg, Switzerland
  • Guggisberg, Adrian G. ORCID Department of Clinical Neuroscience, Division of Neurorehabilitation, Geneva University Hospital, Geneva, Switzerland
  • Chabwine, Joelle N. ORCID Faculty of Science and Medicine, Department of Neuroscience and Movement Science, Laboratory for Neurorehabilitation Science, Medicine Section, University of Fribourg, Fribourg, Switzerland, Neurorehabilitation Division, Fribourg Hospital Meyriez/Murten, Fribourg, Switzerland
Show more…
  • 21.02.2023
Published in:
  • PLOS ONE. - Public Library of Science. - 2023, vol. 18, p. 1-12
Pain
Fibromyalgia
Electroencephalography
Amygdala
Pain sensation
Neuropathic pain
Central nervous system
Prefrontal cortex
English Fibromyalgia (FM) is a major chronic pain disease with prominent affective disturbances, and pain-associated changes in neurotransmitters activity and in brain connectivity. However, correlates of affective pain dimension lack. The primary goal of this correlational cross-sectional case-control pilot study was to find electrophysiological correlates of the affective pain component in FM. We examined the resting-state EEG spectral power and imaginary coherence in the beta (β) band (supposedly indexing the GABAergic neurotransmission) in 16 female patients with FM and 11 age-adjusted female controls. FM patients displayed lower functional connectivity in the High β (Hβ, 20–30 Hz) sub-band than controls (p = 0.039) in the left basolateral complex of the amygdala (p = 0.039) within the left mesiotemporal area, in particular, in correlation with a higher affective pain component level (r = 0.50, p = 0.049). Patients showed higher Low β (Lβ, 13–20 Hz) relative power than controls in the left prefrontal cortex (p = 0.001), correlated with ongoing pain intensity (r = 0.54, p = 0.032). For the first time, GABA-related connectivity changes correlated with the affective pain component are shown in the amygdala, a region highly involved in the affective regulation of pain. The β power increase in the prefrontal cortex could be compensatory to pain-related GABAergic dysfunction.
Faculty
Faculté des sciences et de médecine
Department
Master en médecine
Language
  • English
Classification
Pharmacology, therapeutics, toxicology
License
CC BY
Open access status
gold
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/325297
Statistics
Document views: 23 File downloads:
  • journal.pone.0281986.pdf: 48