Journal article
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Seroprevalence trends of anti-SARS-CoV-2 antibodies and associated risk factors: a population-based study
DOKPE
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Tancredi, Stefano
Population Health Laboratory, University of Fribourg
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Chiolero, Arnaud
ORCID
Population Health Laboratory (#PopHealthLab), University of Fribourg, Route Des Arsenaux 41, 1700, Fribourg, Switzerland / School of Population and Global Health, McGill University, Montreal, Canada / Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland
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Wagner, Cornelia
ORCID
Population Health Laboratory (#PopHealthLab), University of Fribourg, Route Des Arsenaux 41, 1700, Fribourg, Switzerland
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Haller, Moa Lina
Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland / Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
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Chocano-Bedoya, Patricia
ORCID
Population Health Laboratory (#PopHealthLab), University of Fribourg, Route Des Arsenaux 41, 1700, Fribourg, Switzerland / Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland
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Ortega, Natalia
ORCID
Population Health Laboratory (#PopHealthLab), University of Fribourg, Route Des Arsenaux 41, 1700, Fribourg, Switzerland / Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland
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Rodondi, Nicolas
Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland / Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
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Kaufmann, Laurent
Cantonal Public Health Service of the Canton of Neuchâtel, Neuchâtel, Switzerland
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Lorthe, Elsa
Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland
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Baysson, Hélène
ORCID
Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland / Department of Health and Community Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland
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Stringhini, Silvia
ORCID
Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland / Department of Health and Community Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland / University Center for General Medicine and Public Health, University of Lausanne, Lausanne, Switzerland
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Michel, Gisela
ORCID
Department Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland
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Lüdi, Chantal
ORCID
Department Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland
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Harju, Erika
ORCID
Department Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland / Clinical Trial Unit, Lucerne Cantonal Hospital, Lucerne, Switzerland
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Frank, Irene
Clinical Trial Unit, Lucerne Cantonal Hospital, Lucerne, Switzerland
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Imboden, Medea
ORCID
Swiss Tropical and Public Health Institute, Allschwil, Switzerland / University of Basel, Basel, Switzerland
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Witzig, Melissa
ORCID
Swiss Tropical and Public Health Institute, Allschwil, Switzerland / University of Basel, Basel, Switzerland
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Keidel, Dirk
ORCID
Swiss Tropical and Public Health Institute, Allschwil, Switzerland / University of Basel, Basel, Switzerland
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Probst-Hensch, Nicole
ORCID
Swiss Tropical and Public Health Institute, Allschwil, Switzerland / University of Basel, Basel, Switzerland
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Amati, Rebecca
ORCID
Institute of Public Health, Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland
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Albanese, Emiliano
ORCID
Institute of Public Health, Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland
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Corna, Laurie
ORCID
Department of Business Economics, Health and Social Care, University of Applied Sciences and Arts of Southern Switzerland, Manno, Switzerland
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Crivelli, Luca
ORCID
Department of Business Economics, Health and Social Care, University of Applied Sciences and Arts of Southern Switzerland, Manno, Switzerland
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Vincentini, Julia
Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland
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Gonseth Nusslé, Semira
ORCID
Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland
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Bochud, Murielle
Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland
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D’Acremont, Valérie
ORCID
Swiss Tropical and Public Health Institute, Allschwil, Switzerland / Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland
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Kohler, Philipp
ORCID
Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St Gallen, St Gallen, Switzerland
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Kahlert, Christian R.
ORCID
Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St Gallen, St Gallen, Switzerland / Department of Infectious Diseases and Hospital Epidemiology, Children’s Hospital of Eastern Switzerland, St. Gallen, Switzerland
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Cusini, Alexia
Division of Infectious Diseases, Cantonal Hospital of Grisons, Chur, Switzerland
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Frei, Anja
ORCID
Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland
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Puhan, Milo A.
ORCID
Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland
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Geigges, Marco
Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland
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Kaufmann, Marco
ORCID
Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland
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Fehr, Jan
ORCID
Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland
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Cullati, Stéphane
ORCID
Population Health Laboratory (#PopHealthLab), University of Fribourg, Route Des Arsenaux 41, 1700, Fribourg, Switzerland / Department of Readaptation and Geriatrics, University of Geneva, Geneva, Switzerland
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the Corona Immunitas Research Group
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Published in:
- Infection. - Springer Science and Business Media LLC. - 2023
English
Purpose: We aimed to assess the seroprevalence trends of SARS-CoV-2 antibodies in several Swiss cantons between May 2020 and September 2021 and investigate risk factors for seropositivity and their changes over time.
Methods: We conducted repeated population-based serological studies in different Swiss regions using a common methodology. We defined three study periods: May-October 2020 (period 1, prior to vaccination), November 2020-mid-May 2021 (period 2, first months of the vaccination campaign), and mid-May-September 2021 (period 3, a large share of the population vaccinated). We measured anti-spike IgG. Participants provided information on sociodemographic and socioeconomic characteristics, health status, and adherence to preventive measures. We estimated seroprevalence with a Bayesian logistic regression model and the association between risk factors and seropositivity with Poisson models.
Results: We included 13,291 participants aged 20 and older from 11 Swiss cantons. Seroprevalence was 3.7% (95% CI 2.1-4.9) in period 1, 16.2% (95% CI 14.4-17.5) in period 2, and 72.0% (95% CI 70.3-73.8) in period 3, with regional variations. In period 1, younger age (20-64) was the only factor associated with higher seropositivity. In period 3, being aged ≥ 65 years, with a high income, retired, overweight or obese or with other comorbidities, was associated with higher seropositivity. These associations disappeared after adjusting for vaccination status. Seropositivity was lower in participants with lower adherence to preventive measures, due to a lower vaccination uptake.
Conclusions: Seroprevalence sharply increased over time, also thanks to vaccination, with some regional variations. After the vaccination campaign, no differences between subgroups were observed.
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Faculty
- Faculté des sciences et de médecine
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Department
- Master en médecine
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Language
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Classification
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Medicine
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License
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CC BY
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Open access status
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hybrid
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/324166
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