Journal article

+ 1 other files

Seroprevalence trends of anti-SARS-CoV-2 antibodies and associated risk factors: a population-based study

DOKPE

  • Tancredi, Stefano Population Health Laboratory, University of Fribourg
  • Chiolero, Arnaud ORCID Population Health Laboratory (#PopHealthLab), University of Fribourg, Route Des Arsenaux 41, 1700, Fribourg, Switzerland / School of Population and Global Health, McGill University, Montreal, Canada / Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland
  • Wagner, Cornelia ORCID Population Health Laboratory (#PopHealthLab), University of Fribourg, Route Des Arsenaux 41, 1700, Fribourg, Switzerland
  • Haller, Moa Lina Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland / Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
  • Chocano-Bedoya, Patricia ORCID Population Health Laboratory (#PopHealthLab), University of Fribourg, Route Des Arsenaux 41, 1700, Fribourg, Switzerland / Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland
  • Ortega, Natalia ORCID Population Health Laboratory (#PopHealthLab), University of Fribourg, Route Des Arsenaux 41, 1700, Fribourg, Switzerland / Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland
  • Rodondi, Nicolas Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland / Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
  • Kaufmann, Laurent Cantonal Public Health Service of the Canton of Neuchâtel, Neuchâtel, Switzerland
  • Lorthe, Elsa Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland
  • Baysson, Hélène ORCID Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland / Department of Health and Community Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland
  • Stringhini, Silvia ORCID Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland / Department of Health and Community Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland / University Center for General Medicine and Public Health, University of Lausanne, Lausanne, Switzerland
  • Michel, Gisela ORCID Department Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland
  • Lüdi, Chantal ORCID Department Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland
  • Harju, Erika ORCID Department Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland / Clinical Trial Unit, Lucerne Cantonal Hospital, Lucerne, Switzerland
  • Frank, Irene Clinical Trial Unit, Lucerne Cantonal Hospital, Lucerne, Switzerland
  • Imboden, Medea ORCID Swiss Tropical and Public Health Institute, Allschwil, Switzerland / University of Basel, Basel, Switzerland
  • Witzig, Melissa ORCID Swiss Tropical and Public Health Institute, Allschwil, Switzerland / University of Basel, Basel, Switzerland
  • Keidel, Dirk ORCID Swiss Tropical and Public Health Institute, Allschwil, Switzerland / University of Basel, Basel, Switzerland
  • Probst-Hensch, Nicole ORCID Swiss Tropical and Public Health Institute, Allschwil, Switzerland / University of Basel, Basel, Switzerland
  • Amati, Rebecca ORCID Institute of Public Health, Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland
  • Albanese, Emiliano ORCID Institute of Public Health, Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland
  • Corna, Laurie ORCID Department of Business Economics, Health and Social Care, University of Applied Sciences and Arts of Southern Switzerland, Manno, Switzerland
  • Crivelli, Luca ORCID Department of Business Economics, Health and Social Care, University of Applied Sciences and Arts of Southern Switzerland, Manno, Switzerland
  • Vincentini, Julia Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland
  • Gonseth Nusslé, Semira ORCID Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland
  • Bochud, Murielle Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland
  • D’Acremont, Valérie ORCID Swiss Tropical and Public Health Institute, Allschwil, Switzerland / Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland
  • Kohler, Philipp ORCID Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St Gallen, St Gallen, Switzerland
  • Kahlert, Christian R. ORCID Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St Gallen, St Gallen, Switzerland / Department of Infectious Diseases and Hospital Epidemiology, Children’s Hospital of Eastern Switzerland, St. Gallen, Switzerland
  • Cusini, Alexia Division of Infectious Diseases, Cantonal Hospital of Grisons, Chur, Switzerland
  • Frei, Anja ORCID Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland
  • Puhan, Milo A. ORCID Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland
  • Geigges, Marco Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland
  • Kaufmann, Marco ORCID Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland
  • Fehr, Jan ORCID Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland
  • Cullati, Stéphane ORCID Population Health Laboratory (#PopHealthLab), University of Fribourg, Route Des Arsenaux 41, 1700, Fribourg, Switzerland / Department of Readaptation and Geriatrics, University of Geneva, Geneva, Switzerland
  • the Corona Immunitas Research Group
Show more…
  • 04.03.2023
Published in:
  • Infection. - Springer Science and Business Media LLC. - 2023
English Purpose: We aimed to assess the seroprevalence trends of SARS-CoV-2 antibodies in several Swiss cantons between May 2020 and September 2021 and investigate risk factors for seropositivity and their changes over time.
Methods: We conducted repeated population-based serological studies in different Swiss regions using a common methodology. We defined three study periods: May-October 2020 (period 1, prior to vaccination), November 2020-mid-May 2021 (period 2, first months of the vaccination campaign), and mid-May-September 2021 (period 3, a large share of the population vaccinated). We measured anti-spike IgG. Participants provided information on sociodemographic and socioeconomic characteristics, health status, and adherence to preventive measures. We estimated seroprevalence with a Bayesian logistic regression model and the association between risk factors and seropositivity with Poisson models.
Results: We included 13,291 participants aged 20 and older from 11 Swiss cantons. Seroprevalence was 3.7% (95% CI 2.1-4.9) in period 1, 16.2% (95% CI 14.4-17.5) in period 2, and 72.0% (95% CI 70.3-73.8) in period 3, with regional variations. In period 1, younger age (20-64) was the only factor associated with higher seropositivity. In period 3, being aged ≥ 65 years, with a high income, retired, overweight or obese or with other comorbidities, was associated with higher seropositivity. These associations disappeared after adjusting for vaccination status. Seropositivity was lower in participants with lower adherence to preventive measures, due to a lower vaccination uptake.
Conclusions: Seroprevalence sharply increased over time, also thanks to vaccination, with some regional variations. After the vaccination campaign, no differences between subgroups were observed.
Faculty
Faculté des sciences et de médecine
Department
Master en médecine
Language
  • English
Classification
Medicine
License
CC BY
Open access status
hybrid
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/324166
Other files

Statistics

Document views: 35 File downloads:
  • s15010-023-02011-01.pdf: 31
  • 15010_2023_2011_MOESM1_ESM.pdf: 40