Journal article

Proactive inhibition is not modified by deep brain stimulation for Parkinson's disease : an electrical neuroimaging study


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  • 2021
Published in:
  • Human Brain Mapping. - Wiley. - 2021, vol. 42, no. 12, p. 3934-3949
English In predictable contexts, motor inhibitory control can be deployed before the actual
need for response suppression. The brain functional underpinnings of proactive inhibition,
and notably the role of basal ganglia, are not entirely identified. We investigated
the effects of deep brain stimulation of the subthalamic nucleus or internal
globus pallidus on proactive inhibition in patients with Parkinson's disease. They
completed a cued go/no-go proactive inhibition task ON and (unilateral) OFF stimulation
while EEG was recorded. We found no behavioural effect of either subthalamic
nucleus or internal globus pallidus deep brain stimulation on proactive inhibition,
despite a general improvement of motor performance with subthalamic nucleus stimulation.
In the non-operated and subthalamic nucleus group, we identified periods of
topographic EEG modulation by the level of proactive inhibition. In the subthalamic
nucleus group, source estimation analysis suggested the initial involvement of bilateral
frontal and occipital areas, followed by a right lateralized fronto-basal network,
and finally of right premotor and left parietal regions. Our results confirm the overall
preservation of proactive inhibition capacities in both subthalamic nucleus and internal
globus pallidus deep brain stimulation, and suggest a partly segregated network
for proactive inhibition, with a preferential recruitment of the indirect pathway.
Faculté des sciences et de médecine
Médecine 3ème année
  • English
Open access status
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