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Optogenetic stimulation of basal forebrain parvalbumin neurons activates the default mode network and associated behaviors

  • Lozano-Montes, Laura Section of Medicine, University of Fribourg, 1700 Fribourg, Switzerland
  • Dimanico, Marta Section of Medicine, University of Fribourg, 1700 Fribourg, Switzerland
  • Mazloum, Reza Section of Medicine, University of Fribourg, 1700 Fribourg, Switzerland
  • Li, Wenxue Section of Medicine, University of Fribourg, 1700 Fribourg, Switzerland
  • Nair, Jayakrishnan Section of Medicine, University of Fribourg, 1700 Fribourg, Switzerland
  • Kintscher, Michael Laboratory of Synaptic Mechanisms, Brain Mind Institute, School of Life Science, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
  • Schneggenburger, Ralf Laboratory of Synaptic Mechanisms, Brain Mind Institute, School of Life Science, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
  • Harvey, Michael Section of Medicine, University of Fribourg, 1700 Fribourg, Switzerland
  • Rainer, Gregor Section of Medicine, University of Fribourg, 1700 Fribourg, Switzerland
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    10.11.2020
Published in:
  • Cell Reports. - 2020, vol. 33, no. 6, p. 108359
English Activation of the basal forebrain (BF) has been associated with increased attention, arousal, and a heightened cortical representation of the external world. In addition, BF has been implicated in the regulation of the default mode network (DMN) and associated behaviors. Here, we provide causal evidence for a role of BF in DMN regulation, highlighting a prominent role of parvalbumin (PV) GABAergic neurons. The optogenetic activation of BF PV neurons reliably drives animals toward DMN-like behaviors, with no effect on memory encoding. In contrast, BF electrical stimulation enhances memory performance and increases DMN-like behaviors. BF stimulation has a correlated impact on peptide regulation in the BF and ACC, enhancing peptides linked to grooming behavior and memory functions, supporting a crucial role of the BF in DMN regulation. We suggest that in addition to enhancing attentional functions, the BF harbors a network encompassing PV GABAergic neurons that promotes self- directed behaviors associated with the DMN.
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/309397
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