Journal article

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Biophysics of temporal interference stimulation

  • Mirzakhalili, Ehsan Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA - Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA
  • Barra, Beatrice Department of Neuroscience and Movement Science, University of Fribourg, Fribourg, Switzerland - Rehab and Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA 15213, USA
  • Capogrosso, Marco Rehab and Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA 15213, USA - Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA - Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA -
  • Lempka, Scott F. Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA - Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA - Department of Anesthesiology, University of Michigan, Ann Arbor, MI 48109, USA -
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    16.12.2020
Published in:
  • Cell Systems. - 2020, vol. 11, no. 6, p. 557-572.e5
English Temporal interference (TI) is a non-invasive neurostimulation technique that utilizes high-frequency external electric fields to stimulate deep neuronal structures without affecting superficial, off-target structures. TI represents a potential breakthrough for treating conditions, such as Parkinson’s disease and chronic pain. However, early clinical work on TI stimulation was met with mixed outcomes challenging its fundamental mechanisms and applications. Here, we apply established physics to study the mechanisms of TI with the goal of optimizing it for clinical use. We argue that TI stimulation cannot work via passive membrane filtering, as previously hypothesized. Instead, TI stimulation requires an ion-channel mediated signal rectification process. Unfortunately, this mechanism is also responsible for high- frequency conduction block in off-target tissues, thus challenging clinical applications of TI. In consequence, we propose a set of experimental controls that should be performed in future experiments to refine our understanding and practice of TI stimulation
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/309379
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