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Responsive nanofibers with embedded hierarchical lipid self-assemblies

  • Tien, Nguyen D. Center for X-Ray Analytics, Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen CH-9014, Switzerland - Laboratory for Biomimetic Membranes and Textiles, Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen CH-9014, Switzerland
  • Maurya, Anjani K. Center for X-Ray Analytics, Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen CH-9014, Switzerland - Laboratory for Biomimetic Membranes and Textiles, Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen CH-9014, Switzerland - Cellular and Biomedical Sciences, Faculty of Medicine, University of Bern, Bern CH-3012, Switzerland
  • Fortunato, Giuseppino Laboratory for Biomimetic Membranes and Textiles, Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen CH-9014, Switzerland
  • Rottmar, Markus Laboratory for Biointerfaces, Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen CH-9014, Switzerland
  • Zboray, Robert Center for X-Ray Analytics, Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen CH-9014, Switzerland
  • Erni, Rolf Electron Microscopy Center, Empa, Swiss Federal Laboratories for Materials Science and Technology, Dübendorf CH-8600, Switzerland
  • Dommann, Alex Center for X-Ray Analytics, Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen CH-9014, Switzerland - Cellular and Biomedical Sciences, Faculty of Medicine, University of Bern, Bern CH-3012, Switzerland
  • Rossi, René M. Laboratory for Biomimetic Membranes and Textiles, Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen CH-9014, Switzerland
  • Neels, Antonia Center for X-Ray Analytics, Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen CH-9014, Switzerland - Department of Chemistry, University of Fribourg, Fribourg 79085, Switzerland
  • Sadeghpour, Amin Center for X-Ray Analytics, Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen CH-9014, Switzerland - Laboratory for Biomimetic Membranes and Textiles, Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen CH-9014, Switzerland
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    13.10.2020
Published in:
  • Langmuir. - 2020, vol. 36, no. 40, p. 11787–11797
English We introduce the design and study of a hybrid electrospun membrane with a dedicated nanoscale structural hierarchy for controlled functions in the biomedical domain. The hybrid system comprises submicrometer-sized internally self-assembled lipid nanoparticles (ISAsomes or mesosomes) embedded into the electrospun membrane with a nanofibrous polymer network. The internal structure of ISAsomes, studied by small-angle X-ray scattering (SAXS) and electron microscopy, demonstrated a spontaneous response to variations in the environmental conditions as they undergo a bicontinuous inverse cubic phase (cubosomes) in solution to a crystalline lamellar phase in the polymer membrane; nevertheless, this phase reorganization is reversible. As revealed by in situ SAXS measurements, if the membrane was put in contact with aqueous media, the cubic phase reappeared and submicrometer-sized cubosomes were released upon dissolution of the nanofibers. Furthermore, the hybrid membranes exhibited a specific anisotropic feature and morphological response under an external strain. While nanofibers were aligned under external strain in the microscale, the semicrystalline domains from the polymer phase were positioned perpendicular to the lamellae of the lipid phase in the nanoscale. The fabricated membranes and their spontaneous responses offer new strategies for the development of structure-controlled functions in electrospun nanofibers for biomedical applications, such as drug delivery or controlled interactions with biointerfaces.
Faculty
Faculté des sciences et de médecine
Department
Département de Chimie
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/309204
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